Transformation reactions between Pneumococcus and three strains of Streptococci.
Transformation reactions between Pneumococcus and three strains of Streptococci.
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DOI：
10.1084/jem.106.2.247
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发表时间：
1957-08-01
期刊：
影响因子：
--
通讯作者：
MACLEOD CM
中科院分区：
文献类型：
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作者：
BRACCO RM;KRAUSS MR;ROE AS;MACLEOD CM
肺炎球菌和2株绿色链球菌之间对链霉素耐药性的相互转化反应已被证明，按照通常的细菌学标准，这两株菌株与肺炎球菌有较远的亲缘关系。已发现一株链霉素耐药唾液链球菌的脱氧核糖核酸(DNA)提取物能够转化肺炎球菌和两株绿色链球菌，但该菌株本身不能被自体或异源DNA提取物转化。作为自体和异体转化原理的受体，这两株绿色链球菌比肺炎球菌更有效。因此，可以推断，转化效率并不一定表明细菌之间的亲缘关系密切。3株链球菌的转化原理(TP‘s)在肺炎球菌中重复后，诱导链霉菌对链霉素耐药的效率提高。同时，其中两种茶多酚转化链球菌的效率也降低了。对视黄素(乙基氢化铜)的抗药性是大多数链球菌的特征，可通过转化反应转移到肺炎球菌，这是一种自然敏感的物种。
Reciprocal transformation reactions to streptomycin resistance have been demonstrated between pneumococcus and 2 strains of viridans streptococci, which by the usual bacteriological criteria are distantly related to pneumococcus. Desoxyribonucleic acid (DNA) extracts of a strain of streptomycin-resistant Streptococcus salivarius have been found capable of transforming pneumococcus and two strains of viridans streptococci but the strain itself was not transformed by autologous or heterologous DNA extracts. The two strains of viridans streptococci were more efficient than pneumococcus as receptors of both autologous and heterologous transforming principles. It is inferred, therefore, that efficiency of transformation does not necessarily indicate closeness of relationship among bacteria. The efficiency of transforming principles (TP's) from three streptococcal strains to induce streptomycin resistance in pneumococcus increased following their reduplication in pneumococcus. At the same time the efficiency of two of these TP's to transform streptococcus was reduced. Resistance to optochin (ethylhydrocupreine), a characteristic of most streptococci, can be transferred to pneumococcus, a naturally susceptible species, by transformation reactions.