Subclinical delusional thinking predicts lateral temporal cortex responses during social reflection
Subclinical delusional thinking predicts lateral temporal cortex responses during social reflection
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DOI：
10.1093/scan/nss129
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发表时间：
2014-03-01
影响因子：
4.2
通讯作者：
Holt, Daphne J.
中科院分区：
文献类型：
--
作者：
Brent, Benjamin K.;Coombs, Garth;Holt, Daphne J.
神经影像学研究表明，精神病性妄想与涉及社会认知的大脑区域异常之间存在关联，这些区域包括内侧前额叶皮层 (MPFC)、后扣带皮层和外侧颞叶皮层 (LTC)。一般人群研究将亚临床妄想思维与社会认知受损联系起来，提出了社会感知过程中大脑活动的特定模式是否与妄想信念相关的问题。在这里，我们测试了这样的假设：亚临床妄想思维与神经功能的变化有关，而受试者对自己或他人做出判断[“社会反思”（SR）]。使用功能性磁共振成像对 22 名健康受试者进行了 SR 和非社交任务期间的神经反应以及静息状态活动的测量。妄想思维是使用 Peters 等人测量的。妄想清单。妄想思维与 SR 期间左侧 LTC 的反应（r = -0.61，P = 0.02，Bonferroni 校正）以及左侧 LTC 和左腹侧 MPFC 之间的连接呈负相关，并与左侧 LTC 和右侧中额叶和颞下皮质之间的连接呈正相关。因此，一般人群的妄想性思维可能与 SR 相关皮质区域的活动减少和功能连接异常有关。
Neuroimaging studies have demonstrated associations between delusions in psychotic disorders and abnormalities of brain areas involved in social cognition, including medial prefrontal cortex (MPFC), posterior cingulate cortex, and lateral temporal cortex (LTC). General population studies have linked subclinical delusional thinking to impaired social cognition, raising the question of whether a specific pattern of brain activity during social perception is associated with delusional beliefs. Here, we tested the hypothesis that subclinical delusional thinking is associated with changes in neural function, while subjects made judgments about themselves or others ['social reflection' (SR)]. Neural responses during SR and non-social tasks, as well as resting-state activity, were measured using functional magnetic resonance imaging in 22 healthy subjects. Delusional thinking was measured using the Peters et al. Delusions Inventory. Delusional thinking was negatively correlated with responses of the left LTC during SR (r = -0.61, P = 0.02, Bonferroni corrected), and connectivity between the left LTC and left ventral MPFC, and was positively correlated with connectivity between the left LTC and the right middle frontal and inferior temporal cortices. Thus, delusional thinking in the general population may be associated with reduced activity and aberrant functional connectivity of cortical areas involved in SR.