Glucose-6-phosphate dehydrogenase deficiency: a preventable cause of mental retardation.
Glucose-6-phosphate dehydrogenase deficiency: a preventable cause of mental retardation.
复制标题
6-磷酸葡萄糖脱氢酶缺乏症：智力低下的一个可预防的原因。
DOI：
10.1136/bmj.292.6517.397
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
H. Singh
中科院分区：
文献类型：
--
作者：
H. Singh
在两年多的时间里，对27879名婴儿的脐带血进行了葡萄糖-6-磷酸脱氢酶（G6 PD）缺乏症筛查。男孩的总发病率为3.1%，女孩为1.6%。69名婴儿出现重度黄疸（胆红素浓度大于380 mmol/l（20 mg/100 ml）），并进行了换血。父母被给予书面和口头指示，以避免引发核黄疸的草药和药物，这降低了核黄疸的发生率，从而防止了智力迟钝。G6 PD缺乏症在马来西亚的所有三个种族（马来人、华人和印度人）中都很常见，建议进行筛查。
Over two years cord blood from 27 879 babies was screened for glucose-6-phosphate dehydrogenase (G6PD) deficiency. The overall incidence was 3.1% in boys and 1.6% in girls. Sixty nine babies had severe jaundice (bilirubin concentration greater than 380 mmol/l (20 mg/100 ml], and exchange transfusion was performed. Parents were given written and verbal instructions to avoid herbs and drugs that trigger kernicterus, which reduced the incidence of kernicterus and thereby prevented mental retardation. G6PD deficiency is common in all three ethnic groups (Malays, Chinese, and Indians) in Malaysia and screening is recommended.