ELEVATED CONCENTRATIONS OF CIRCULATING INTERCELLULAR-ADHESION MOLECULE-1 (ICAM-1) AND OF VASCULAR CELL-ADHESION MOLECULE-1 (VCAM-1) IN HIV-1 INFECTION
ELEVATED CONCENTRATIONS OF CIRCULATING INTERCELLULAR-ADHESION MOLECULE-1 (ICAM-1) AND OF VASCULAR CELL-ADHESION MOLECULE-1 (VCAM-1) IN HIV-1 INFECTION
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DOI：
10.3109/15419069509081285
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发表时间：
1995-01-01
期刊：
影响因子：
--
通讯作者：
FERRIERE, F
中科院分区：
文献类型：
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作者：
GATTEGNO, L;BENTATAPEYSSARE, M;FERRIERE, F
本研究的目的是确定与健康HIV血清阴性成人相比，HIV-1感染者血清中循环形式的可溶性黏附分子、细胞间黏附分子-1(CICAM-1)、血管细胞黏附分子-1(cVCAM-1)和E-选择素(Ce-Selectin)水平是否升高，以及这些升高的水平是否与疾病进展相关。29例HIV-1感染者血清中细胞间黏附分子-1和血管细胞黏附分子-1水平显著高于对照组(P<；0.001)，分别为653~3456 ng/ml和328~792 ng/ml(P<0.05)。HIV-1感染者的血清Ce-选择素浓度与健康对照组无明显差异。CICAM-1、cVCAM-1水平升高与CD_4细胞计数及血清C-反应蛋白浓度均无相关性。然而，cVCAM-1的血清浓度与新喋呤之间存在显著的相关性。由于CICAM-1和cVCAM-1可以干扰导致免疫功能的黏附事件，因此可以认为，当HIV-1感染者的血清中存在大量这些循环形式的黏附分子时，可能会进一步扰乱这些患者的免疫系统。此外，本研究还表明，cVCAM-1的血清浓度可以作为原基指示剂。
The aim of this study was to determine whether elevated levels of circulating forms of the soluble adhesion molecules, Intercellular Adhesion Molecule-1 (cICAM-1), Vascular Cell Adhesion Molecule-1 (cVCAM-1) and E-Selectin (cE-Selectin) are observed in the sera of HIV-1 infected individuals as compared to healthy HIV seronegative adults and whether these elevated levels can be correlated with disease progression. Significantly elevated levels of cICAM-1-ranging from 184 to 1116 ng/ml with a mean of 617 ng/ml-and cVCAM-1-ranging from 653 to 3456 ng/ml with a mean of 1500 ng/ml-were observed in the sera of 29 HIV-1 infected individuals as compared to controls ranging from 152 to 354 ng/ml with a mean of 248 ng/ml for cICAM-1 and from 328 to 792 ng/ml with a mean of 560 ng/ml for cVCAM-1 (P < 0.001). The serum concentrations of cE-Selectin of the HIV-1 infected individuals did not differ from those of the healthy controls. The elevated levels of cICAM-1, cVCAM-1 did not correlate with the CD4 count or the serum concentration of C-reactive protein. However, a significant correlation was observed between the serum concentrations of cVCAM-1 and those of neopterin. Since cICAM-1 as well as cVCAM-1 can interfere with adhesion events leading to immunological functions, it can be suggested that the high amounts of these circulating forms of adhesion molecules, when present in the sera of HIV-1 positive individuals, can further disturb the immune system of these patients. In addition, the present study also suggests that the seric concentrations of cVCAM-1 can be used as pronostic indicators.