Fast MR thermometry using an echo-shifted sequence with simultaneous multi-slice imaging
Fast MR thermometry using an echo-shifted sequence with simultaneous multi-slice imaging
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DOI：
10.1007/s10334-018-0692-x
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发表时间：
2018-06
期刊：
影响因子：
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通讯作者：
Yuhong Peng;C. Zou;Y. Qiao;Changjun Tie;Qian Wan;R. Jiang;Chuanli Cheng;D. Liang;Hairong Zheng;Faqi Li;Xin Liu
中科院分区：
文献类型：
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作者：
Yuhong Peng;C. Zou;Y. Qiao;Changjun Tie;Qian Wan;R. Jiang;Chuanli Cheng;D. Liang;Hairong Zheng;Faqi Li;Xin Liu
目的实时监测对高强度聚焦超声（HIFU）治疗的安全性和有效性具有重要意义。磁共振成像是HIFU监测的首选成像方式，具有独特的温度成像能力。实时温度成像需要更高的时间分辨率和更大的空间覆盖范围。在这项研究中，一个序列的基础上的回波移位RF扰相梯度回波（GRE）与同步多切片（SMS）imaging的设计快速temperature imaging.MethodsA体模实验进行评估的准确性的回波移位序列使用荧光纤维温度计作为参考。通过离体猪肌肉，在室温下比较了回波移位序列与传统GRE序列的温度不确定度。最后，离体猪肝组织实验使用HIFU加热进行证明，空间覆盖范围增加而不降低时间resolution.ResultsThe回波移位序列有更好的温度不确定性性能相比，传统的GRE序列具有相同的时间分辨率。离体加热实验证实，通过结合SMS技术和回波移位序列，空间覆盖率增加，而不会降低时间分辨率，同时保持高的温度测量precision.ConclusionThe所提出的技术被验证为一种有效的实时监测HIFU治疗的方法。
PurposeReal-time monitoring is important for the safety and effectiveness of high-intensity focused ultrasound (HIFU) therapy. Magnetic resonance imaging is the preferred imaging modality for HIFU monitoring, with its unique capability of temperature imaging. For real-time temperature imaging, higher temporal resolution and larger spatial coverage are needed. In this study, a sequence based on the echo-shifted RF-spoiled gradient echo (GRE) with simultaneous multi-slice (SMS) imaging was designed for fast temperature imaging.MethodsA phantom experiment was conducted to evaluate the accuracy of the echo-shifted sequence using a fluorescent fiber thermometer as reference. The temperature uncertainty of the echo-shifted sequence was compared with the traditional GRE sequence at room temperature through the ex vivo porcine muscle. Finally, the ex vivo porcine liver tissue experiment using HIFU heating was performed to demonstrate that the spatial coverage was increased without decreasing temporal resolution.ResultsThe echo-shifted sequence had a better temperature uncertainty performance compared with the traditional GRE sequence with the same temporal resolution. The ex vivo heating experiment confirmed that by combining the SMS technique and echo-shifted sequence, the spatial coverage was increased without decreasing the temporal resolution while maintaining high temperature measurement precision.ConclusionThe proposed technique was validated as an effective real-time method for monitoring HIFU therapy.