N-acetylcysteine reduces extinction responding and induces enduring reductions in cue-and heroin-induced drug-seeking
N-acetylcysteine reduces extinction responding and induces enduring reductions in cue-and heroin-induced drug-seeking
复制标题
N-乙酰半胱氨酸减少灭绝反应，并持久减少线索和海洛因诱导的药物寻求
DOI：
10.1016/j.biopsych.2007.06.008
复制
发表时间：
2008-02-01
影响因子：
10.6
通讯作者：
Kalivas, Peter W.
中科院分区：
文献类型：
--
作者：
Zhou, Wenhua;Kalivas, Peter W.
背景资料：以往的研究表明，急性给药的N-乙酰半胱氨酸（NAC）抑制可卡因成瘾者和可卡因seeking.Methods：大鼠训练自我管理海洛因，药物寻求的恢复模型被用来确定是否慢性NAC治疗抑制海洛因seeking.Results：每日NAC管理抑制线索和海洛因诱导的寻求。此外，重复NAC管理在灭绝训练减少的防御反应和抑制线索和海洛因诱导的恢复长达40天后，停止每日NAC injection.Conclusions：这些数据表明，每日NAC抑制海洛因诱导的恢复，并产生持久的减少线索和海洛因诱导的药物寻求超过一个月后，最后一次注射NAC。NAC对海洛因寻求的恢复的抑制作用和NAC减少戒断反应的能力都支持重复给予NAC以减少海洛因成瘾者的药物寻求的临床评价。
Background: Previous studies show that the acute administration of N-acetylcysteine (NAC) inhibits the desire for cocaine in addicts and cocaine-seeking in animals.Methods: Rats were trained to self-administer heroin, and the reinstatement model of drug seeking was used to determine whether chronic NAC treatment inhibited heroin-seeking.Results: Daily NAC administration inhibited cue- and heroin-induced seeking. Moreover, repeated NAC administration during extinction training reduced extinction-responding and inhibited cue- and heroin-induced reinstatement for up to 40 days after discontinuing daily NAC injection.Conclusions: These data show that daily NAC inhibits heroin-induced reinstatement and produces an enduring reduction in cue- and heroin-induced drug seeking for over I month after the last injection of NAC. Both the inhibitory effect of NAC on the reinstatement of heroin-seeking and the ability of NAC to reduce extinction-responding support clinical evaluation of repeated NAC administration to decrease in drug-seeking in heroin addicts.