A novel protein with strong homology to the tumor suppressor p53
A novel protein with strong homology to the tumor suppressor p53
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DOI：
10.1038/sj.onc.1201500
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发表时间：
1997-09-11
期刊：
影响因子：
8
通讯作者：
Bamberger, C
中科院分区：
文献类型：
--
作者：
Schmale, H;Bamberger, C
P53肿瘤重要基因的凋亡。P53基因缺失的小鼠患癌症的几率很高，但发育正常，这表明在胚胎发生和分化过程中存在代偿机制。新的KET蛋白是第一个在所有进化保守区与P53高度同源的哺乳动物蛋白。这种保守使得这两种蛋白质在细胞周期控制中的功能冗余成为可能。Ket在胚胎发育过程中和某些成体组织中表达。在所有已知的不同物种的P53蛋白中，KET与在鱿鱼中发现的P53蛋白关系最密切。KET与无脊椎动物P53蛋白的关系揭示了P53的进化起源。Ket似乎是脊椎动物祖先中与P53相关的蛋白，可能在发育和分化中发挥作用，而无处不在表达的P53蛋白在进化过程中逐渐成为基因组的守护者。
The p53 tumor important genes apoptosis. Mice deficient for p53 show a high incidence of cancer but are developmentally normal suggesting that compensatory mechanisms exist in embryogenesis and differentiation. The new KET protein is the first mammalian protein with strong homology to p53 in all evolutionary conserved regions. This conservation makes a functional redundancy of the two proteins in cell-cycle control possible. KET is expressed during embryonic development and in certain adult tissues. Among all of the known p53 proteins of different species KET is most closely related to that found in squid. The relationship between KET and the invertebrate p53 protein sheds light on the evolutionary origin of p53. KET appears to be an ancestral p53-related protein in vertebrates,vith a possible role in development and differentiation while the ubiquitously expressed p53 protein attained its general role as 'guardian of the genome' during evolution.