Prolongation of ventricular action potential due to sympathetic stimulation.
Prolongation of ventricular action potential due to sympathetic stimulation.
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由于交感神经刺激而延长心室动作电位。
DOI：
10.1536/ihj.18.259
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
S. Murao
中科院分区：
文献类型：
--
作者：
M. Murayama;K. Harumi;S. Mashima;K. Shimomura;S. Murao
本文用吸引电极分别从狗右心室前表面和左心室后表面刺激星状核，观察了3秒内刺激引起的单相动作电位时程的变化。单相动作电位时程从刺激时的2 ~ 3s延长到刺激结束后的10 ~ 20 s。右心室以右星状体刺激引起的单相动作电位时程延长为主，左心室以左星状体刺激引起的单相动作电位时程延长为主。星状刺激开始后立即发生的体表心电图中的瞬时T波变化可以用心室复极延长的局部差异来解释。由于单相动作电位时程延长的开始先于星状刺激后血压升高，因此单相动作电位时程的延长不是由血流动力学变化引起的，可能是交感神经刺激的主要作用。
The changes of monophasic action potential durations due to stellate stimulation for the period of 3 sec were studied in dogs with suction electrodes from the anterior surface of the right ventricle and the posterior surface of the left ventricle. Prolongation of monophasic action potential duration was observed from the period of 2 to 3 sec during stimulation to that of 10 to 20 sec after the termination of stimulation. Prolongation of monophasic action potential duration due to right stellate stimulation was predominant in the right ventricle and that due to left stellate stimulation was predominant in the left ventricle. The transient T wave change in the surface electrocardiogram occurring immediately after the beginning of stellate stimulation could be explained by this local difference in prolongation of ventricle repolarization. Since the onset of prolongation of monophasic action potential duration preceded increase in blood pressure following stellate stimulation, this prolongation of monophasic action potential duration did not result from the hemodynamic changes and could be a primary effect of the sympathetic nerve stimulation.