Urinary arsenic metabolites in children and adults exposed to arsenic in drinking water in Inner Mongolia, China.
Urinary arsenic metabolites in children and adults exposed to arsenic in drinking water in Inner Mongolia, China.
复制标题
中国内蒙古地区饮用水中砷暴露的儿童和成人的尿砷代谢物。
DOI：
10.1289/ehp.9271
复制
发表时间：
2007-04
影响因子：
10.4
通讯作者：
Sun X
中科院分区：
文献类型：
--
作者：
Sun G;Xu Y;Li X;Jin Y;Li B;Sun X
本文报道了内蒙古呼和浩特市3个自然村233名居民在20、90和160 μg/L无机砷（iAs）暴露后尿砷代谢产物的浓度和分布。我们使用氢化物发生-原子吸收光谱法（HGAAS）测定砷，一甲基胂酸（MMA），二甲基胂酸（DMA）。儿童和成人尿砷浓度均显著高于对照组。与对照组相比，暴露组的儿童和成人的iAs和MMA百分比较高，DMA百分比较低，初级和二级甲基化指数（PMI和SMI）较低。然而，当iAs暴露水平从90 μg/L增加到160 μg/L时，儿童的DMA百分比和SMI显著增加，MMA百分比降低。此外，两个暴露组的儿童表现出较低的MMA百分比，但较高的DMA百分比和较高的SMI比同一暴露组的成年人。各组雄性和雌性之间As代谢物浓度和分布无显著差异。160微克/升接触组的11对儿童及其母亲的SMI也存在显著相关性。当暴露于相同浓度的饮用水中的iAs时，儿童的二级甲基化能力高于成人。砷暴露可能在一定程度上增加儿童的甲基化能力。
We report the concentrations and distributions of urinary arsenic (As) metabolites in 233 residents exposed to 20, 90, or 160 μg/L inorganic arsenic (iAs) in drinking water from three villages in Hohhot, Inner Mongolia, China, that formed one control and two exposed groups. We used hydride generation-atomic absorption spectrometry (HGAAS) to determine iAs, monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA). The concentrations of each urinary As species in the two exposed groups were significantly higher than in the control group for both children and adults. Both children and adults in exposed groups had higher percent iAs and MMA and lower percent DMA, and low primary and secondary methylation indices (PMI and SMI, respectively) than those in the control group. However, children showed significant increases in percent DMA and the SMI as well as decreases in the percent MMA when the iAs exposure level increased from 90 to 160 μg/L. In addition, children in the two exposed groups showed lower percent MMA but higher percent DMA and higher SMI than adults in the same exposed group. No significant differences in As metabolite concentrations and distributions were found between males and females in each group. A significant correlation was also found in the SMI between 11 pairs of children and their mothers from the 160-μg/L–exposed group. Children had higher a capacity for secondary methylation of As than adults when exposed to the same concentrations of iAs in drinking water. Exposure to As may increase the capacity for methylation in children to some extent.