Lung Morphology in the Elderly: Comparative CT Study of Subjects over 75 Years Old versus Those under 55 Years Old
Lung Morphology in the Elderly: Comparative CT Study of Subjects over 75 Years Old versus Those under 55 Years Old
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DOI：
10.1148/radiol.2512081242
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发表时间：
2009-05-01
期刊：
影响因子：
19.7
通讯作者：
Hansell, David M.
中科院分区：
文献类型：
--
作者：
Copley, Susan J.;Wells, Athol U.;Hansell, David M.
目的：描述无症状老年人肺部薄层CT特征。材料和方法：获得机构审查委员会批准，并获得知情同意。两个研究组（老年组，75岁以上;年轻组，55岁以下）是从腹部或脑部CT门诊请求中前瞻性确定的。纳入了五十六名无已知呼吸系统疾病的连续志愿者（老年组：n = 40，18名男性，22名女性;年轻组：n = 16，8名男性，8名女性）。进行俯卧薄层CT成像，两名观察者独立地对图像的CT特征（包括网状结构、毛玻璃样阴影和薄壁囊性气隙）的存在和范围进行评分。组比较，Logistic回归分析被用来评估CT表现与年龄和吸烟history.Results之间的关系：一个有限的主要胸膜下基底网状模式被确定在大多数（24 40，60%）的个人在老年组和缺席（零16）在年轻组（P <0.001）。老年组40例受试者中有10例（25%）观察到囊肿，但年轻组无一例受试者观察到囊肿（P = 0.02）。支气管扩张和管壁增厚在老年组（分别为40例中的24例[60%]和22例[55%]）中的发生率也显著高于年轻组（均为16例中的1例[6%]）（P <0.001）。所有的研究结果是独立的包年吸烟史与多元logistic回归analysis.Conclusion：薄层CT表现通常与间质性肺疾病是常见的无症状的老年人和年轻的受试者缺席。因此，这些结果可能不一定代表临床相关疾病。
Purpose: To describe thin-section pulmonary computed tomographic (CT) features in asymptomatic elderly individuals.Materials and Methods: Institutional review board approval was given, and informed consent was obtained. Two study groups (older group, over 75 years of age; younger group, under 55 years) were prospectively identified from outpatient requests for CT of the abdomen or brain. Fifty-six consecutive volunteers (older group: n = 40, 18 men, 22 women; younger group: n = 16, eight men, eight women) with no known respiratory disease were included. Prone thin-section CT imaging was performed, and two observers independently scored images for the presence and extent of CT features (including reticular pattern, ground glass opacity, and thin-walled cystic air spaces). Group comparisons were made, and logistic regression analysis was used to assess relationships between CT findings and age and smoking history.Results: A limited predominantly subpleural basal reticular pattern was identified in the majority (24 of 40, 60%) of individuals in the older group and was absent (zero of 16) in the younger group (P < .001). Cysts were seen in 10 (25%) of the 40 subjects in the older group but were seen in none of the subjects in the younger group (P = .02). Bronchial dilation and wall thickening were also seen significantly more frequently (P < .001) in the older group (24 [60%] and 22 [55%] of 40, respectively) than in the younger group (both one [6%] of 16). All findings were independent of pack-year smoking history with multiple logistic regression analysis.Conclusion: Thin-section CT findings usually associated with interstitial lung disease are frequently seen in asymptomatic elderly individuals and are absent in younger subjects. Therefore, these findings may not necessarily represent clinically relevant disease.