TTX accumulation in pufferfish
TTX accumulation in pufferfish
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DOI：
10.1016/j.cbd.2005.10.006
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发表时间：
2006-03-01
影响因子：
3
通讯作者：
Takatani, T
中科院分区：
文献类型：
--
作者：
Noguchi, T;Arakawa, O;Takatani, T
河豚毒素(TTX)已在多种动物体内被检测到。在角贝壳中发现TTX强烈表明，它的起源是它的食物，一种带有TTX的海星多棘豆。从那时起，食物链一直被认为是TTX中毒的主要手段。为了确定TTX的主要产生者，对从几个TTX携带者中分离的肠道细菌进行了TTX产生的调查。结果表明，部分菌株能产生TTX。因此，海洋中的主要TTX生产者被认为是海洋细菌。随后，碎屑类摄食者和浮游动物可以通过食物链或与寄生或共生一起中毒TTX。小型食肉动物、食鸟动物或食腐动物以及食物链较高的生物体遵循的过程将导致TTX浓度较高的积累。最后，食物链顶端的河豚会被TTX毒死。网箱和陆地养殖产生的无毒河豚可以通过喂食含TTX的食物而中毒，这一事实支持了这一假说。(C)2005 Elsevier Inc.保留所有权利。
Tetrodotoxin (TTX) has been detected in a variety of animals. The finding of TTX in the trumpet shell Charonia sauliae strongly suggested that its origin was its food, a TTX-bearing starfish Astropecten polyacanthus. Since then, the food chain has been consistently implicated as the principal means of TTX intoxication. To identify the primary producer of TTX, intestinal bacteria isolated from several TTX-bearers were investigated for their TTX production. The results demonstrated that some of them could produce TTX. Thus the primary TTX producers in the sea are concluded to be marine bacteria. Subsequently, detritus feeders and zooplankton can be intoxicated with TTX through the food chain, or in conjunction with parasitism or symbiosis. The process followed by small carnivores, ornnivores or scavengers, and by organisms higher up the food chain would result in the accumulation of higher concentrations of TTX. Finally, pufferfish at the top of the food chain are intoxicated with TTX. This hypothesis is supported by the fact that net cage and land cultures produce non-toxic pufferfish that can be made toxic by feeding with a TTX-containing diet. (c) 2005 Elsevier Inc. All rights reserved.