N-ACETYLASPARTYLGLUTAMATE - POSSIBLE ROLE AS THE NEUROTRANSMITTER OF THE LATERAL OLFACTORY TRACT
N-ACETYLASPARTYLGLUTAMATE - POSSIBLE ROLE AS THE NEUROTRANSMITTER OF THE LATERAL OLFACTORY TRACT
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DOI：
10.1073/pnas.82.11.3897
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发表时间：
1985-01-01
影响因子：
11.1
通讯作者：
CARPENTER, DO
中科院分区：
文献类型：
--
作者：
FFRENCHMULLEN, JMH;KOLLER, K;CARPENTER, DO
N-Acetylaspartylglutamate, an endogenous brain peptide that binds with high affinity to a subpopulation of glutamate-binding sites in rat brain, is excitatory on rat piriform cortex pyramidal cells studied in a perfused brain slice. Both the monosynaptic excitation of the pyramidal cells elicited by stimulation of the lateral olfactory tract and the response to N-acetylaspartylglutamate were blocked by DL-2-amino-4-phosphonobutyrate but not by other excitatory amino acid antagonists. Responses to glutamate and aspartate, previously considered to be candidates as the lateral olfactory tract transmitter, were unaffected by 2-amino-4-phosphonobutyrate. Three days after unilateral bulbectomy there was a significant decrease in concentrations of N-acetylaspartylgutamate as well as aspartate, N-acetylaspartate and .gamma.-GABA in the pyriform cortex of the side from which the olfactory bulb had been removed. N-acetylaspartylglutamate is possibly the endogenous transmitter of the lateral olfactory tract.
