SPECIFIC DECREASES IN ETHANOL- BUT NOT WATER-REINFORCED RESPONDING PRODUCED BY THE 5-HT3 ANTAGONIST ICS 205-930
SPECIFIC DECREASES IN ETHANOL- BUT NOT WATER-REINFORCED RESPONDING PRODUCED BY THE 5-HT3 ANTAGONIST ICS 205-930
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DOI：
10.1016/0741-8329(93)90034-l
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发表时间：
1993-05-01
期刊：
影响因子：
2.3
通讯作者：
ERICKSON, HL
中科院分区：
文献类型：
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作者：
HODGE, CW;SAMSON, HH;ERICKSON, HL
5-羟色胺5-HT 3拮抗剂ICS 205-930已被证明可以阻断乙醇的辨别性刺激特性并减少自愿摄入，这表明5-HT 3系统在乙醇的强化作用中可能起作用。ICS 205-930（0.56、1.0、3.0、10.0和17.0 mg/kg i.p.）的乙醇和水自我管理的操作性范例进行了检查。蔗糖褪色程序后，两组非剥夺大鼠响应于同时固定比例4乙醇（10%v/v）和水（CONC FR 4 FR 4），或乙醇（10%v/v）的单一FR 4时间表。ICS 205-930剂量依赖性地降低了同时条件下的乙醇增强反应，而不降低水增强反应，表明对乙醇的特异性作用。乙醇增强的反应在单一FR 4条件下也呈剂量依赖性降低，但剂量效应曲线左移。这些数据支持以下结论：5-HT 3系统可能在乙醇自我给药中发挥特定作用，其独立于一般食欲和运动过程，并且当多种抑制剂可用时，5-HT 3拮抗剂可能在治疗酒精滥用中具有治疗功效。
The serotonin 5-HT3 antagonist ICS 205-930 has been shown to block the discriminative stimulus properties of ethanol and decrease voluntary intake, suggesting a possible role for 5-HT3 systems in the reinforcing effects of ethanol. ICS 205-930 (0.56, 1.0, 3.0, 10.0, and 17.0 mg/kg i.p.) was examined on ethanol and water self-administration in an operant paradigm. Following a sucrose-fading procedure, two groups of nondeprived rats responded on either a concurrent fixed ratio 4 schedule for ethanol (10% v/v) and water (CONC FR4 FR4), or a single FR4 schedule for ethanol (10% v/v). ICS 205-930 dose-dependently decreased ethanol-reinforced responding in the concurrent condition without decreasing water-reinforced responding, suggesting a specific effect on ethanol. Ethanol-reinforced responding was also dose-dependently decreased in the single FR4 condition, but the dose effect curve was shifted to the left. These data support the conclusions that 5-HT3 systems may play a specific role in ethanol self-administration that is independent of general appetitive and motor processes, and that 5-HT3 antagonists may have therapeutic efficacy in the treatment of alcohol abuse when multiple reinforcers are available.