Effects of stressor controllability on psychophysiological, cognitive and behavioural responses in patients with major depression and dysthymia.
Effects of stressor controllability on psychophysiological, cognitive and behavioural responses in patients with major depression and dysthymia.
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DOI：
10.1017/s0033291708003437
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发表时间：
2009-01
影响因子：
6.9
通讯作者：
Flor H
中科院分区：
文献类型：
--
作者：
Diener C;Kuehner C;Brusniak W;Struve M;Flor H
面对压力时的不可控和无助的体验 生活事件被认为是发展的重要决定因素， 抑郁症的维持。无法成功应对压力源 可能与前额叶功能失调有关我们评估 应激源的认知、行为和生理效应 抑郁和健康个体的不可控性。此外，本发明还提供了一种方法， 改变的皮层处理和认知之间的关系 分析抑郁症的易感性特征。共有26名未经药物治疗的抑郁症患者和24名匹配的健康对照者 在扩展的预警反应（S1-S2）范式中进行测试。 在析因设计中，压力源可控性在三个 连续条件：（a）对照，（B） 失去控制权;（c）恢复控制权。在整个 实验，错误率，可控性，唤醒，情绪 效价和无助感与后祈使句一起评估 脑电图负变（PINV）。抑郁的参与者表现出增强的额叶PINV， 改变的信息处理的电生理学指标 失去控制和恢复控制。他们也感到更加无助 比对照组。此外，额叶PINV幅度与 抑郁子样本中的习惯性沉思。这些发现表明，抑郁症患者更容易受到 压力不可控性高于健康受试者。此外，经验 不可控性似乎会使随后的信息处理产生偏差， 客观上重新确立控制权的情况。的改变 前额叶功能似乎有助于这种脆弱性， 也与抑郁症的特征标记有关。
The experience of uncontrollability and helplessness in the face of stressful life events is regarded as an important determinant in the development and maintenance of depression. The inability to successfully deal with stressors might be linked to dysfunctional prefrontal functioning. We assessed cognitive, behavioural and physiological effects of stressor uncontrollability in depressed and healthy individuals. In addition, relationships between altered cortical processing and cognitive vulnerability traits of depression were analysed. A total of 26 unmedicated depressed patients and 24 matched healthy controls were tested in an expanded forewarned reaction (S1–S2) paradigm. In a factorial design, stressor controllability varied across three consecutive conditions: (a) control, (b) loss of control and (c) restitution of control. Throughout the experiment, error rates, ratings of controllability, arousal, emotional valence and helplessness were assessed together with the post-imperative negative variation (PINV) of the electroencephalogram. Depressed participants showed an enhanced frontal PINV as an electrophysiological index of altered information processing during both loss of control and restitution of control. They also felt more helpless than controls. Furthermore, frontal PINV magnitudes were associated with habitual rumination in the depressed subsample. These findings indicate that depressed patients are more susceptible to stressor uncontrollability than healthy subjects. Moreover, the experience of uncontrollability seems to bias subsequent information processing in a situation where control is objectively re-established. Alterations in prefrontal functioning appear to contribute to this vulnerability and are also linked to trait markers of depression.