Grasping with the Press of a Button: Grasp-selective Responses in the Human Anterior Intraparietal Sulcus Depend on Nonarbitrary Causal Relationships between Hand Movements and End-effector Actions.
Grasping with the Press of a Button: Grasp-selective Responses in the Human Anterior Intraparietal Sulcus Depend on Nonarbitrary Causal Relationships between Hand Movements and End-effector Actions.
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DOI：
10.1162/jocn_a_00766
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发表时间：
2015-06
影响因子：
3.2
通讯作者：
Marchal N
中科院分区：
文献类型：
--
作者：
Frey SH;Hansen M;Marchal N
有证据表明腹侧顶叶前运动皮层在代表抓握的目标时独立于所涉及的运动或效应器[Umilta，M。一、埃斯科拉湖因茨基维利，I.，Grammont，F.，Rochat，M.，Caruana，F.，当钳子变成猴子运动系统中的手指时。美国国家科学院院刊，105，2209-2213，2008; Tunik，E.，Frey，S. H、& Grafton，S. T.前顶内区的虚拟损伤破坏了抓握的目标依赖性在线调整。Nature Neuroscience，8，505-511，2005]。现代技术使手的动作和工具的动作之间的任意因果关系提供了一个强有力的测试这一假设。我们利用这一独特的机会，通过功能磁共振成像记录活动，在任务中，健康的成年人手动执行目标导向的到达和抓取动作，或者通过按下按钮在远程机器人手臂中启动这些相同的行为（任意因果关系）。如前所示[Binkofski，F.，Dohle，C.，波塞，S.，Stephan，K. M.，Hefter，H.，塞茨河J.，人前顶内区保护脑脊髓损伤：一项联合病变和功能性MRI激活研究。Neurology，50，1253-1259，1998]，我们检测到在手动抓握期间与伸手期间前顶内沟（aIPS）附近的活动更大。与先前涉及由非任意相关的手部运动控制的工具的研究相反[Gallivan，J. P.，姆克林，D.一、Valyear，K. F.、&卡勒姆，J. C.解码人类工具使用的神经机制。Elife，2，e00425，2013; Jacobs，S.，Danielmeier，C.，& Frey，S. H.人类前顶叶内和腹侧前运动皮质支持用手或新工具抓握的表征。Journal of Cognitive Neuroscience，22，2594-2608，2010]，然而，当参与者使用机器人时，aIPS和前运动皮层内的反应没有表现出抓握选择性的证据。相反，这些地区表现出相当的增加活动在达到和掌握条件。尽管有相同的感觉运动需求，当参与者启动机器人的动作时，右小脑半球表现出更大的活动，而不是当他们按下一个已知不起作用的按钮并观看自主进行的相同动作时。这支持了小脑预测意志行为即将发生的感觉后果的假设[Blakemore，S。J.，弗里斯角D、& Wolpert，D. M.小脑参与预测动作的感觉结果。NeuroReport，12，1879-1884，2001]。我们的结论是，在人类aIPS和前运动皮层的抓握选择性反应依赖于手的运动和末端效应器的行动之间的非任意因果关系的存在。
Evidence implicates ventral parieto-premotor cortices in representing the goal of grasping independent of the movements or effectors involved [Umilta, M. A., Escola, L., Intskirveli, I., Grammont, F., Rochat, M., Caruana, F., et al. When pliers become fingers in the monkey motor system. Proceedings of the National Academy of Sciences, U.S.A., 105, 2209–2213, 2008; Tunik, E., Frey, S. H., & Grafton, S. T. Virtual lesions of the anterior intraparietal area disrupt goal-dependent on-line adjustments of grasp. Nature Neuroscience, 8, 505–511, 2005]. Modern technologies that enable arbitrary causal relationships between hand movements and tool actions provide a strong test of this hypothesis. We capitalized on this unique opportunity by recording activity with fMRI during tasks in which healthy adults performed goal-directed reach and grasp actions manually or by depressing buttons to initiate these same behaviors in a remotely located robotic arm (arbitrary causal relationship). As shown previously [Binkofski, F., Dohle, C., Posse, S., Stephan, K. M., Hefter, H., Seitz, R. J., et al. Human anterior intraparietal area subserves prehension: A combined lesion and functional MRI activation study. Neurology, 50, 1253–1259, 1998], we detected greater activity in the vicinity of the anterior intraparietal sulcus (aIPS) during manual grasp versus reach. In contrast to prior studies involving tools controlled by nonarbitrarily related hand movements [Gallivan, J. P., McLean, D. A., Valyear, K. F., & Culham, J. C. Decoding the neural mechanisms of human tool use. Elife, 2, e00425, 2013; Jacobs, S., Danielmeier, C., & Frey, S. H. Human anterior intraparietal and ventral premotor cortices support representations of grasping with the hand or a novel tool. Journal of Cognitive Neuroscience, 22, 2594–2608, 2010], however, responses within the aIPS and premotor cortex exhibited no evidence of selectivity for grasp when participants employed the robot. Instead, these regions showed comparable increases in activity during both the reach and grasp conditions. Despite equivalent sensorimotor demands, the right cerebellar hemisphere displayed greater activity when participants initiated the robot’s actions versus when they pressed a button known to be nonfunctional and watched the very same actions undertaken autonomously. This supports the hypothesis that the cerebellum predicts the forthcoming sensory consequences of volitional actions [Blakemore, S. J., Frith, C. D., & Wolpert, D. M. The cerebellum is involved in predicting the sensory consequences of action. NeuroReport, 12, 1879–1884, 2001]. We conclude that grasp-selective responses in the human aIPS and premotor cortex depend on the existence of nonarbitrary causal relationships between hand movements and end-effector actions.