von Willebrand factor: at the crossroads of bleeding and thrombosis
von Willebrand factor: at the crossroads of bleeding and thrombosis
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DOI：
10.1007/s12185-012-1041-x
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发表时间：
2012-04-01
影响因子：
2.1
通讯作者：
Lenting, Peter J.
中科院分区：
文献类型：
--
作者：
Denis, Cecile V.;Lenting, Peter J.
止血和血栓形成是同一枚硬币的两面。止血维持血管系统中的血液流动性，同时允许快速血栓形成以防止血管损伤后过度出血。血栓形成是正常止血机制的病理延伸，在某些病理情况下发生不必要的凝块形成。这两种现象背后的分子机制基本上是相同的。血浆糖蛋白von Willebrand因子是这两个过程中的关键参与者之一，它完美地说明了止血和血栓形成机制之间的二元性。这篇综述的目的是讨论新的发现的作用，血管性血友病因子在这个接口，以及如何这些发现可能有助于开发新的治疗策略。
Hemostasis and thrombosis represent two sides of the same coin. Hemostasis maintains blood fluidity in the vascular system while allowing for rapid thrombus formation to prevent excessive hemorrhage after blood vessel injury. Thrombosis is a pathologic extension of the normal hemostatic mechanism, occurring when unwanted clot formation develops in certain pathological situations. The molecular mechanisms underlying both phenomena are fundamentally identical. One of the key players in both processes is the plasma glycoprotein von Willebrand factor, which perfectly illustrates this duality between hemostatic and thrombotic mechanisms. The purpose of this review is to discuss novel findings on the role of von Willebrand factor at this interface, and how some of these findings may help develop new therapeutic strategies.