Bipolar Disorder and Comorbid Personality Psychopathology: A Review of the Literature
Bipolar Disorder and Comorbid Personality Psychopathology: A Review of the Literature
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DOI：
10.4088/jcp.v69n1115
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发表时间：
2008-11-01
影响因子：
5.3
通讯作者：
Hassell, Joseph
中科院分区：
文献类型：
--
作者：
Fan, Alexander H.;Hassell, Joseph
目的：探讨人格障碍合并症在双相情感障碍患者中的患病率及其对双相情感障碍患者的影响。数据来源：所有的研究都是通过PubMed网站的在线文献搜索找到的。这些研究发表于1980年至2006年之间。以下关键词用于搜索文章：双相，躁狂，情绪，人格，II轴，边缘性和锂。本文献综述仅收录英文文章。研究选择：我们回顾了共32项关于双相情感障碍患者共病性人格障碍或异常人格特征的患病率和影响的研究。数据提取：从患病率研究中提取的数据包括样本量、研究人群的情绪状态、用于确定人格精神病理学的研究工具、人格障碍和异常的患病率。收集的其他数据包括对药物的反应和病程。数据综合：患病率研究分为门诊研究和住院研究，便于数据分析。根据人格病理学的研究工具，对患病率研究进行了分析。使用非dsm人格测量的研究被单独分析。结论：双相情感障碍患者的人格障碍患病率明显高于一般人群。几项研究表明，情绪不稳定的双相患者中II轴障碍的患病率较高。然而，这一发现并没有在住院和门诊合并症发生率的比较中得到证实。具有人格精神病理学的双相患者对药物的反应较差，病程更致命。
Objective: To examine the prevalence of personality disorder comorbidity in bipolar disorder and examine the effects of this comorbidity on bipolar disorder patients.Data Sources: All the studies reviewed were found through an online literature search through the Web site PubMed. The Studies were published between 1980 and 2006. The following keywords were used to search articles: bipolar, mania, mood, personality, Axis II, borderline, and lithium. Only articles in English were included in this literature review.Study Selection: A total of 32 studies that reported data oil the prevalence and effect of comorbid personality disorders or abnormal personality traits in bipolar disorder patients were reviewed.Data Extraction: The data abstracted from the prevalence studies included sample size, mood state of the Study population, research instruments used to determine personality psychopathology, prevalence rates of personality disorders, and abnormalities. Other data collected included response to medications and course of illness.Data Synthesis: The prevalence studies were categorized into outpatient and inpatient Studies to facilitate data analysis. The prevalence studies were also analyzed according to the research instrument used to measure personality pathology. Studies that used non-DSM personality measures were analyzed separately.Conclusions: Bipolar disorder patients have significantly higher prevalence of personality disorder than the general population. Several studies reviewed indicate a higher prevalence of Axis II disorders in bipolar patients with unstable mood. However, this finding was not confirmed in comparison of inpatient and outpatient comorbidity rates. Bipolar patients with personality psychopathology have poorer response to medications and a more virulent course of illness.