Effect of ammonium salts on brain metabolism
Effect of ammonium salts on brain metabolism
复制标题
铵盐对脑代谢的影响
DOI：
10.1136/jnnp.37.8.948
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
C. Xanalatos
中科院分区：
文献类型：
--
作者：
I. James;L. Macdonnell;C. Xanalatos
将乙酸铵（13 m-mol）、碳酸氢铵（13 m-mol）和氢氧化铵（30 m-mol）静脉给予三个独立的组，每组5只犬。在15分钟内给予乙酸铵和碳酸氢铵，给予氢氧化铵30分钟。在所有狗中，在15分钟的输液后，血氨浓度与肝昏迷患者相似。当给予氢氧化铵30分钟时，在所有研究犬中均观察到麻醉减轻。此时，两只动物的血氨值超过1，000 μg/100 ml。输注终止后观察到随后的麻醉加深。在所有研究的动物中，脑葡萄糖消耗增加，氧利用率变化不大。在给予碳酸氢铵的组中研究了动脉乳酸，发现其在葡萄糖利用增加的同时增加。酸铵盐和碱铵盐均可诱发肺换气过度。乳酸酸中毒似乎是过度通气的原因而不是结果。讨论了过度通气对脑代谢的保护作用。
Ammonium acetate (13 m-mol), ammonium bicarbonate (13 m-mol), and ammonium hydroxide (30 m-mol) were administered intravenously to three separate groups of five dogs. Ammonium acetate and bicarbonate were given over a period of 15 minutes, ammonium hydroxide was given for 30 minutes. In all dogs, after 15 minutes' infusion, the blood ammonia concentration was similar to that found in patients with hepatic coma. When the ammonium hydroxide had been given for 30 minutes, lightening of anaesthesia was noted in all dogs studied. At this time blood ammonia values were over 1,000 μg/100 ml in two animals. Subsequent deepening of anaesthesia was observed after termination of the infusion. In all animals studied there was an increase in cerebral glucose consumption with little change in oxygen utilization. Arterial lactic acid was studied in the group given ammonium bicarbonate and found to increase at the same time as the increase in glucose utilization. Hyperventilation was precipitated by both acid and alkalilne ammonium salts. Lactic acidosis appeared to be the cause rather than the result of the hyperventilation. The protective effect of hyperventilation on brain metabolism is discussed.