Corticosteroids may improve clinical outcomes during hospitalization for Henoch-Schönlein purpura.
Corticosteroids may improve clinical outcomes during hospitalization for Henoch-Schönlein purpura.
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DOI：
10.1542/peds.2009-3348
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发表时间：
2010-10
期刊：
影响因子：
8
通讯作者：
Feudtner C
中科院分区：
文献类型：
--
作者：
Weiss PF;Klink AJ;Localio R;Hall M;Hexem K;Burnham JM;Keren R;Feudtner C
To characterize the effect of corticosteroid exposure on clinical outcomes in children hospitalized with new-onset Henoch-Schönlein purpura (HSP). We conducted a retrospective cohort study of children discharged with an International Classification of Diseases, Clinical Modification code of HSP between 2000 and 2007 by using inpatient administrative data from 36 tertiary care children’s hospitals. We used stratified Cox proportional hazards regression models to estimate the relative effect of time-varying corticosteroid exposure on the risks of clinical outcomes that occur during hospitalization for acute HSP. During the 8-year study period, there were 1895 hospitalizations for new-onset HSP. After multivariable regression modeling adjustment, early corticosteroid exposure significantly reduced the hazard ratios for abdominal surgery (0.39 [95% confidence interval (CI): 0.17– 0.91]), endoscopy (0.27 [95% CI: 0.13– 0.55]), and abdominal imaging (0.50 [95% CI: 0.29 – 0.88]) during hospitalization. In the hospital setting, early corticosteroid exposure was associated with benefits for several clinically relevant HSP outcomes, specifically those related to the gastrointestinal manifestations of the disease.
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影响因子：
8
作者：
Feudtner, Chris;Levin, James E.;Hall, Matt
通讯作者：
Hall, Matt
影响因子：
3.6
作者：
MOLLICA, F;LIVOLTI, S;RUSSO, G
通讯作者：
RUSSO, G
影响因子：
5.1
作者：
Ronkainen, Jaana;Koskimies, Olli;Nuutinen, Mati
通讯作者：
Nuutinen, Mati
影响因子：
1.6
作者：
Calviño, MC;Llorca, J;González-Gay, MA
通讯作者：
González-Gay, MA
影响因子：
9.3
作者：
Huber, Adam M.;King, Jim;Pothos, Mary
通讯作者：
Pothos, Mary