Method for patient-specific finite element modeling and simulation of deep brain stimulation
Method for patient-specific finite element modeling and simulation of deep brain stimulation
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DOI：
10.1007/s11517-008-0411-2
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发表时间：
2009-01-01
影响因子：
3.2
通讯作者：
Wardell, Karin
中科院分区：
文献类型：
--
作者：
Astrom, Mattias;Zrinzo, Ludvic U.;Wardell, Karin
脑深部电刺激（DBS）是帕金森病的一种既定治疗方法。DBS的成功高度依赖于电极位置和电参数设置。本研究的目的是开发一种基于磁共振图像建立DBS患者特定3D计算机模型的通用方法，并证明使用此类模型评估电极触点的位置和与个体患者解剖结构相关的电场分布。开发了一个用于创建有限元DBS模型的软件工具。在一名患者中模拟DBS产生的电场，并使用等值线和字形可视化结果。对结果进行了评价，结果与报告的刺激效果和副作用相符。结果表明，DBS的患者特定有限元模型和模拟可用于增加对DBS临床结局的理解。
Deep brain stimulation (DBS) is an established treatment for Parkinson's disease. Success of DBS is highly dependent on electrode location and electrical parameter settings. The aim of this study was to develop a general method for setting up patient-specific 3D computer models of DBS, based on magnetic resonance images, and to demonstrate the use of such models for assessing the position of the electrode contacts and the distribution of the electric field in relation to individual patient anatomy. A software tool was developed for creating finite element DBS-models. The electric field generated by DBS was simulated in one patient and the result was visualized with isolevels and glyphs. The result was evaluated and it corresponded well with reported effects and side effects of stimulation. It was demonstrated that patient-specific finite element models and simulations of DBS can be useful for increasing the understanding of the clinical outcome of DBS.