Longitudinal study of cervical squamous intraepithelial lesions in human immunodeficiency virus (HIV)-seropositive and at-risk HIV-seronegative women
Longitudinal study of cervical squamous intraepithelial lesions in human immunodeficiency virus (HIV)-seropositive and at-risk HIV-seronegative women
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DOI：
10.1086/375783
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发表时间：
2003-07-01
影响因子：
6.4
通讯作者：
Shah, KV
中科院分区：
文献类型：
--
作者：
Schuman, P;Ohmit, SE;Shah, KV
我们研究了774名人类免疫缺陷病毒(HIV)血清阳性和391名HIV血清阴性妇女的异常宫颈细胞学检查结果的发生率及其进展和消退的相关性，这些异常细胞学检查结果被定义为至少低级别鳞状上皮内病变(SILS)，最长为5.5年。在随访期间，224名(35%)艾滋病毒血清阳性妇女和34名(9%)艾滋病毒血清阴性妇女出现了巴氏试验检测到的偶发SILS；47名(7%)艾滋病毒血清阳性妇女发展为高度病变。在每100人年的观察中，HIV血清阳性妇女中SILS的发病率为11.5例，HIV血清阴性妇女中为2.6例(比率比为4.5；95%可信区间为3.1-6.4；P<；.001)。有CD4(+)淋巴细胞计数的HIV血清阳性妇女发生SILS的风险和巴氏试验进展的可能性增加
We examined incidence and correlates of progression and regression of abnormal cervical cytologic test results, defined as at least low-grade squamous intraepithelial lesions (SILs), in 774 human immunodeficiency virus (HIV)-seropositive and 391 HIV-seronegative women monitored semiannually for up to 5.5 years. During follow-up, 224 (35%) HIV-seropositive women and 34 (9%) HIV-seronegative women had incident SILs detected by Pap test; 47 (7%) HIV-seropositive women developed high-grade lesions. The incidence of SILs was 11.5 cases among HIV-seropositive and 2.6 cases among HIV-seronegative women per 100 person-years of observation (rate ratio, 4.5; 95% confidence interval, 3.1-6.4; P < .001). Risk of incident SILs and likelihood of Pap test progression were increased among HIV-seropositive women with CD4(+) lymphocyte counts