IGA ANTIBODIES TO DIETARY ANTIGENS AND LECTIN-BINDING IGA IN SERA FROM ITALIAN, AUSTRALIAN, AND JAPANESE IGA NEPHROPATHY PATIENTS
IGA ANTIBODIES TO DIETARY ANTIGENS AND LECTIN-BINDING IGA IN SERA FROM ITALIAN, AUSTRALIAN, AND JAPANESE IGA NEPHROPATHY PATIENTS
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DOI：
10.1016/s0272-6386(12)80644-5
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发表时间：
1991-04-01
影响因子：
13.2
通讯作者：
TOMINO, Y
中科院分区：
文献类型：
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作者：
COPPO, R;AMORE, A;TOMINO, Y
我们研究了血清伊加作为抗体的饮食抗原（Ag），凝集素结合分子，并作为conglutin-binding免疫复合物（IgAIC）的人从地理区域，其中伊加肾病（IgAGN）是特别频繁。研究了63名意大利人、21名澳大利亚人和25名日本人IgAGN患者的血清以及24名意大利人、20名澳大利亚人和40名日本人健康对照。在42.8%的意大利患者中检测到IgAIC值升高，而在澳大利亚和日本患者中分别仅为23.8%和8%。仅意大利患者的平均值显著增加（P< 0.0001）。伊加抗体对饮食Ag阳性值有可变的患病率，但意大利患者再次显示出最高的频率，从19%至28.5%，澳大利亚人为0至38%，日本人为0至16%。与相应的健康人群相比，任何患者组中这些抗体的平均值均未显著增加。然而，IgAIC值升高的患者有显着较高的血清抗体浓度的食物成分和线性相关性之间的IgAIC和一些伊加抗体的食物成分。这两个系列的数据之间的关系是特别明显的意大利和澳大利亚IgAGN患者。此外，有阳性数据的患者倾向于同时具有针对多种食物Ag的伊加抗体水平升高的群集。谷蛋白组分和异源白蛋白的伊加抗体值之间的线性相关性是明显的。这些相关性在健康对照组中均不明显。除了抗体的作用外，研究患者血清中的一些伊加能够通过非免疫键结合几种凝集素，这种非免疫键被竞争性糖抑制。将患者的数据与相应的对照组进行比较，我们发现高达72%的日本患者，高达56%的澳大利亚人和6%至33%的意大利人的凝集素结合伊加活性增加。只有在日本患者的血清凝集素结合伊加活性的平均值显着增加，但没有相关性与IgAIC水平。这些数据表明，IgAGN患者的血清伊加可能参与免疫复合物的形成与伊加结合的消化道抗原，也形成非免疫复合物的IgA-凝集素相互作用。
We studied serum IgA as antibodies to dietary antigens (Ag), as lectin-binding molecules, and as conglutininbinding immune complexes (IgAIC) in people from geographical areas in which IgA nephropathy (IgAGN) is particularly frequent. Sera from 63 Italian, 21 Australian, and 25 Japanese patients affected by IgAGN and 24 Italian, 20 Australian, and 40 Japanese healthy controls were studied. Increased values of IgAIC were detected in 42.8% of Italian patients, while only in 23.8% and 8% of Australian and Japanese patients, respectively. Mean values were significantly increased only in Italian patients (P< 0.0001). Positive values of IgA antibodies against dietary Ag had variable prevalences, but again Italian patients showed the highest frequency, from 19% to 28.5% versus 0 to 38% in Australians and 0 to 16% in Japanese. Mean values of these antibodies were not significantly increased in any patient groups in comparison to the corresponding healthy populations. However, patients with elevated values of IgAIC had significantly higher serum concentrations of antibodies to alimentary components and a linear correlation was found between IgAIC and some IgA antibodies to food components. The relationship between these two series of data was particularly evident for Italian and Australian IgAGN patients. Moreover, the patients with positive data tended to have a cluster of increased levels of IgA antibodies against several alimentary Ag at the same time. A linear correlation was evident between values of IgA antibodies to gluten fractions and to heterologous albumins. None of these correlations was evident among healthy controls. Besides the role of the antibodies, some IgA in sera from the patients investigated were able to bind several lectins by a nonimmune bond, which was inhibited by competitive sugars. Comparing patients' data with the corresponding controls, we found increased lectin-binding IgA activity in up to 72% of Japanese patients, in up to 56% of Australians, and in 6% to 33% of Italians. Only in Japanese patients' sera were mean values of lectin-binding IgA activity significantly increased, but without correlation with IgAIC levels. These data suggest that serum IgA in IgAGN patients may participate in immune complex formation with IgA binding to alimentary antigens and also forming nonimmune complexes by IgA-lectin interactions.