Low-cost, portable optical imaging systems for cancer diagnosis.
Low-cost, portable optical imaging systems for cancer diagnosis.
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DOI：
10.1109/iembs.2010.5627330
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Richards-Kortum R
中科院分区：
文献类型：
--
作者：
Pierce MC;Richards-Kortum R
全球癌症发病率和死亡率继续上升，疾病负担日益向发展中国家转移。目前正在开发几种光学诊断方法，如漫射光学断层扫描、宽视场自身荧光成像、共聚焦显微镜和光学相干断层扫描，以实现癌症的早期检测。然而，这些主要用于工业化国家的卫生保健设施。利用从这些大规模系统的早期临床研究中获得的知识，我们设计并测试了这些仪器的低成本便携式版本。我们建议这些系统可以用于发展中国家的早期诊断和筛查，并且在这些资源匮乏的环境中进行试点临床研究是有必要的。
Worldwide incidence and mortality rates due to cancer continue to rise, with the burden of disease increasingly shifting to developing countries. Several optical diagnostic methods such as diffuse optical tomography, wide-field autofluorescence imaging, confocal microscopy, and optical coherence tomography, are currently under development to enable earlier detection of cancer. However, these are primarily intended for use in healthcare facilities in industrialized countries. Using knowledge gained from early clinical studies with these large-scale systems, we have designed and tested low-cost, portable versions of these instruments. We propose that these systems may be used for early diagnosis and screening in developing countries, and that pilot clinical studies are warranted in these low-resource settings.