Filopodia in cell adhesion, 3D migration and cancer cell invasion
Filopodia in cell adhesion, 3D migration and cancer cell invasion
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DOI：
10.1016/j.ceb.2015.06.007
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发表时间：
2015-10-01
影响因子：
7.5
通讯作者：
Ivaska, Johanna
中科院分区：
文献类型：
--
作者：
Jacquemet, Guillaume;Hamidi, Hellyeh;Ivaska, Johanna
本文综述了丝状足和丝状足样结构在体外和体内细胞粘附和三维（3D）细胞迁移中的作用的最新进展。特别是，我们关注最近的进展，证明丝状足参与底物系结和体内环境感知。我们进一步讨论了丝状伪足和丝状伪足蛋白在肿瘤传播中的新作用，越来越多的体外、体内和临床证据表明，丝状伪足驱动癌细胞侵袭，并强调丝状伪足蛋白是有吸引力的治疗靶点。最后，我们概述了仍有待解决的突出问题，以阐明丝状足在3D细胞迁移中的作用。
This review discusses recent advances in our understanding of the role filopodia and filopodia-like structures in cell adhesion and three dimensional (3D) cell migration both in vitro and in vivo. In particular, we focus on recent advances demonstrating that filopodia are involved in substrate tethering and environment sensing in vivo. We further discuss the emerging role of filopodia and filopodial proteins in tumor dissemination as mounting in vitro, in vivo and clinical evidence suggest that filopodia drive cancer cell invasion and highlight filopodia proteins as attractive therapeutic targets. Finally, we outline outstanding questions that remain to be addressed to elucidate the role of filopodia during 3D cell migration.