Ca2+-Signal Transduction Inhibitors, Kujiol A and Kujigamberol B, Isolated from Kuji Amber Using a Mutant Yeast
Ca2+-Signal Transduction Inhibitors, Kujiol A and Kujigamberol B, Isolated from Kuji Amber Using a Mutant Yeast
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DOI：
10.1021/acs.jnatprod.7b00922
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发表时间：
2018-04-01
影响因子：
5.1
通讯作者：
Kimura, Ken-ichi
中科院分区：
文献类型：
--
作者：
Uchida, Takeshi;Koshino, Hiroyuki;Kimura, Ken-ichi
从苦枝琥珀中分离得到一种罗汉果三烯衍生物，分别命名为苦枝醇A [13-甲基-8，11，13-罗汉果三烯-19-醇（1）]和苦枝甘贝罗醇B [15，20-二去甲-5，7，9-labdatrien-13-醇（2）]，并对其抗突变酵母菌株的生长恢复活性进行了检测（zds 1 Delta，erg 3 Delta pdr 1 Delta pdr 3 Delta），已知其对Ca 2+信号传导高度敏感。通过光谱数据分析鉴定了结构。化合物1和2是罕见的有机化合物，从晚白垩世琥珀，和突变酵母似乎有用的阐明各种新化合物从久治琥珀标本，K-Pg边界之前产生的。
A podocarpatriene and a labdatriene derivative, named kujiol A [13-methyl-8,11,13-podocarpatrien-19-ol (1)] and kujigamberol B [15,20-dinor-5,7,9-labdatrien-13-ol (2)], respectively, were isolated from Kuji amber through detection with the aid of their growth-restoring activity against a mutant yeast strain (zds1 Delta, erg3 Delta pdr1 Delta pdr3 Delta), which is known to be hypersensitive with respect to Ca2+-signal transduction. The structures were elucidated by spectroscopic data analysis. Compounds 1 and 2 are rare organic compounds from Late Cretaceous amber, and the mutant yeast used seems useful for elucidating a variety of new compounds from Kuji amber specimens, produced before the K-Pg boundary.