Chronic hepatitis C virus infection in the United States, National Health and Nutrition Examination Survey 2003 to 2010.
Chronic hepatitis C virus infection in the United States, National Health and Nutrition Examination Survey 2003 to 2010.
复制标题
DOI：
10.7326/m13-1133
复制
发表时间：
2014-03-04
影响因子：
39.2
通讯作者：
Holmberg SD
中科院分区：
文献类型：
--
作者：
Denniston MM;Jiles RB;Drobeniuc J;Klevens RM;Ward JW;McQuillan GM;Holmberg SD
了解美国患有慢性丙型肝炎病毒（HCV）感染的人数对于公共卫生和政策计划至关重要。
为了估计2003年至2010年之间慢性HCV感染的患病率，并确定与此情况相关的因素。
全国代表性的家庭调查。
美国非机构化的平民。
30 074 NHANES（国家卫生和营养检查调查）参与者在2003年至2010年之间。
访谈以确定人口特征以及HCV感染的可能风险和暴露。测试了6岁或6岁以上参与者的血清样品，以抗HCV的抗体；如果结果为阳性或不确定，则测试样品的HCV RNA，这表明当前的慢性感染。
基于273名对HCV RNA呈阳性的参与者，HCV感染的估计患病率为1.0％（95％CI，0.8％至1.2％），对应于270万慢性感染者（CI，2.2至320万人）美国非机构化的平民。感染者更有可能年龄40至59岁，男性和非西班牙裔黑人，受教育程度较低，家庭收入较低。与慢性HCV感染显着相关的因素是非法药物使用（包括注射药物）和1992年之前接受输血的因素； HCV感染的患者中有49％没有报告任何这两种危险因素。
未对被监禁和无家可归的人进行调查。
该分析估计，NHANES取样的人群中约有270万美国居民患有慢性HCV感染，比1999年至2002年之间的类似分析中的估计少500 000。将它们与适当的护理和治疗联系起来。
没有任何。
Knowledge of the number of persons with chronic hepatitis C virus (HCV) infection in the United States is critical for public health and policy planning. To estimate the prevalence of chronic HCV infection between 2003 and 2010 and to identify factors associated with this condition. Nationally representative household survey. U.S. noninstitutionalized civilian population. 30 074 NHANES (National Health and Nutrition Examination Survey) participants between 2003 and 2010. Interviews to ascertain demographic characteristics and possible risks and exposures for HCV infection. Serum samples from participants aged 6 years or older were tested for antibody to HCV; if results were positive or indeterminate, the samples were tested for HCV RNA, which indicates current chronic infection. Based on 273 participants who tested positive for HCV RNA, the estimated prevalence of HCV infection was 1.0% (95% CI, 0.8% to 1.2%), corresponding to 2.7 million chronically infected persons (CI, 2.2 to 3.2 million persons) in the U.S. noninstitutionalized civilian population. Infected persons were more likely to be aged 40 to 59 years, male, and non-Hispanic black and to have less education and lower family income. Factors significantly associated with chronic HCV infection were illicit drug use (including injection drugs) and receipt of a blood transfusion before 1992; 49% of persons with HCV infection did not report either risk factor. Incarcerated and homeless persons were not surveyed. This analysis estimated that approximately 2.7 million U.S. residents in the population sampled by NHANES have chronic HCV infection, about 500 000 fewer than estimated in a similar analysis between 1999 and 2002. These data underscore the urgency of identifying the millions of persons who remain infected and linking them to appropriate care and treatment. None.