The microRNA-200 family: small molecules with novel roles in cancer development, progression and therapy.
The microRNA-200 family: small molecules with novel roles in cancer development, progression and therapy.
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DOI：
10.18632/oncotarget.3052
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发表时间：
2015-03-30
期刊：
影响因子：
--
通讯作者：
Yang C
中科院分区：
文献类型：
--
作者：
Humphries B;Yang C
microRNA（miRNAs）是一类非编码小RNA，通过5′端种子区与3′端非翻译区之间的碱基配对，在转录后负调控蛋白质编码基因的表达。最近的证据支持miRNAs在包括癌症在内的许多疾病中发挥的关键作用。miR-200家族由5个成员（miR-200 a、-200b、-200c、-141、-429）组成，是一个新兴的miRNA家族，在肿瘤的发生和转移中发挥重要作用，对肿瘤的诊断和治疗具有重要意义。虽然发现miR-200在小鼠乳腺异种移植肿瘤模型中关键地参与转移性定殖至肺，但大量研究证明其对细胞转化、癌细胞增殖、迁移、侵袭、肿瘤生长和转移具有强抑制作用。本文就miR-200家族在肿瘤发生、肿瘤转移级联反应的各个环节、肿瘤诊断和治疗中的作用进行综述。还提供了目前验证的miR-200靶点的全面总结。结论：miR-200家族可能成为多种肿瘤治疗的新靶点。
MicroRNAs (miRNAs) are a large family of small non-coding RNAs that negatively regulate protein-coding gene expression post-transcriptionally via base pairing between the 5′ seed region of a miRNA and the 3′ untranslated region (3′UTR) of a messenger RNA (mRNA). Recent evidence has supported the critical role that miRNAs play in many diseases including cancer. The miR-200 family consisting of 5 members (miR-200a, -200b, -200c, -141, -429) is an emerging miRNA family that has been shown to play crucial roles in cancer initiation and metastasis, and potentially be important for the diagnosis and treatment of cancer. While miR-200s were found to be critically involved in the metastatic colonization to the lungs in mouse mammary xenograft tumor models, a large number of studies demonstrated their strong suppressive effects on cell transformation, cancer cell proliferation, migration, invasion, tumor growth and metastasis. This review aims to discuss research findings about the role of the miR-200 family in cancer initiation, each step of cancer metastatic cascade, cancer diagnosis and treatment. A comprehensive summary of currently validated miR-200 targets is also presented. It is concluded that miR-200 family may serve as novel targets for the therapy of multiple types of cancer.
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