Full-Color-Tunable Nanohydrogels as High-Stability Intracellular Nanothermometers.
Full-Color-Tunable Nanohydrogels as High-Stability Intracellular Nanothermometers.
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DOI：
10.1021/acsami.2c18201
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发表时间：
2022-12
影响因子：
9.5
通讯作者：
Zhen Wang;Yu Miao;Qiang Ou;Ruo-Xin Niu;Yi Jiang;Chun Zhang
中科院分区：
文献类型：
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作者：
Zhen Wang;Yu Miao;Qiang Ou;Ruo-Xin Niu;Yi Jiang;Chun Zhang
具有热稳定性的全色可调水凝胶可用于各种领域，包括细胞内温度传感。然而，构建具有优异生物相容性和稳定性的全色可调有机纳米水凝胶用于细胞内温度传感仍然是一个巨大的挑战。在这里，我们报告了一个全颜色可调的纳米水凝胶与水稳定性作为细胞内的纳米温度计。合成了三种具有红色、绿色和蓝色荧光的温敏聚合物。通过调节这三种聚合物的质量比，这些聚合物可以被编码为全色可调的荧光纳米水凝胶，包括具有白光发射（NWLE）的纳米水凝胶，在水性介质中具有约200 nm的尺寸。进一步的研究表明，所获得的NWLEs表现出良好的性能，在细胞内的温度传感，因为它们的荧光性质和形态的稳定性。
Full-color-tunable hydrogels with ultrahigh stability can be used in various fields, including intracellular temperature sensing. However, constructing full-color-tunable organic nanohydrogels with excellent biocompatibility and stability for intracellular temperature sensing remains a great challenge. Here, we report a full-color-tunable nanohydrogel with ultrahigh stability as an intracellular nanothermometer. Three types of temperature-sensitive polymers with red, green, and blue fluorescence were synthesized. Through easy mixing of these three polymers with regulation of the mass ratio, these polymers can be encoded to full-color-tunable fluorescent nanohydrogels, including nanohydrogels with white-light emission (NWLEs), with sizes of about 200 nm in aqueous media. Further study suggested that the as-obtained NWLEs exhibited good performance in intracellular temperature sensing because of their ultrahigh stability on their fluorescence properties and morphologies.