Chronic hepatitis B increases mortality and complexity among HIV-coinfected patients in South Africa: a cohort study.
Chronic hepatitis B increases mortality and complexity among HIV-coinfected patients in South Africa: a cohort study.
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慢性乙型肝炎会增加南非艾滋病毒合并感染患者的死亡率和复杂性：一项队列研究。
DOI：
10.1111/hiv.12367
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发表时间：
2016
期刊：
影响因子：
3
通讯作者：
Hoffmann,CJ
中科院分区：
文献类型：
--
作者：
Velen,K;Charalambous,S;Innes,C;Churchyard,GJ;Hoffmann,CJ
ObjectivesTo assess the effect of chronic hepatitis B on survival and clinical complexity among people living with HIV after antiretroviral therapy（ART）starting.MethodsWe evaluated mortality and single‐drug substitution up to 3 years from ART starting（中位随访2.75年;四分位数间距2-3年）在有和无慢性B型肝炎（CH B）的患者中结果与非CH B患者相比，CH B患者中B病毒（HBV）DNA水平> 10 000拷贝/mL（校正风险比3.1; 95%置信区间1.2-8.0）的死亡率增加。我们没有观察到非CHB患者与CHB和HBV DNA < 10 000拷贝/mL的患者之间存在类似的差异（校正风险比0.70; 95%置信区间0.2-2.3）。无论HBV DNA水平如何，在合并感染的患者中，单药替代发生的频率更高。
ObjectivesTo assess the effect of chronic hepatitis B on survival and clinical complexity among people living with HIV following antiretroviral therapy (ART) initiation.MethodsWe evaluated mortality and single‐drug substitutions up to 3 years from ART initiation (median follow‐up 2.75 years; interquartile range 2–3 years) among patients with and without chronic hepatitis B (CHB) enrolled in a workplace HIV care programme in South Africa.ResultsMortality was increased for CHB patients with hepatitis B virus (HBV) DNA levels > 10 000 copies/mL (adjusted hazard ratio 3.1; 95% confidence interval 1.2–8.0) compared with non‐CHB patients. We did not observe a similar difference between non‐CHB patients and those with CHB and HBV DNA < 10 000 copies/mL (adjusted hazard ratio 0.70; 95% confidence interval 0.2–2.3). Single‐drug substitutions occurred more frequently among coinfected patients regardless of HBV DNA level.ConclusionsOur findings suggest that CHB may increase mortality and complicate ART management.