PlasmoDB:: the Plasmodium genome resource.: A database integrating experimental and computational data
PlasmoDB:: the Plasmodium genome resource.: A database integrating experimental and computational data
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DOI：
10.1093/nar/gkg081
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发表时间：
2003-01-01
影响因子：
14.9
通讯作者：
Whetzel, P
中科院分区：
文献类型：
--
作者：
Bahl, A;Brunk, B;Whetzel, P
PlasmoDB（PlasmoDB.org）是恶性疟原虫基因组测序联盟的官方数据库。该资源包括最近完成的恶性疟原虫基因组序列和注释，以及来自其他疟原虫测序项目的序列草案和注释。PlasmoDB目前包含来自五种寄生虫物种的信息，并为物种内和物种间的比较提供工具。序列信息与其他基因组规模的数据从疟原虫研究界出现，包括基因表达分析EST，SAGE和微阵列项目和蛋白质组学研究。用于构建PlasmoDB的关系模式GUS（基因组学统一模式）采用高度结构化的格式来适应序列和表达项目生成的各种数据类型。各种工具使研究人员能够制定复杂的，基于生物学的数据库查询。该数据库的一个独立版本也以光盘形式提供（恶性疟原虫基因图），方便在难以上网的情况下（例如在实地工作的疟疾研究人员）查阅数据。PlasmoDB的目标是促进利用全球疟疾研究界产生的大量基因组规模数据。用于开发PlasmoDB的软件已用于创建第二个顶复门寄生虫基因组数据库ToxoDB（ToxoDB.org）。
PlasmoDB (http://PlasmoDB.org) is the official database of the Plasmodium falciparum genome sequencing consortium. This resource incorporates the recently completed P. falciparum genome sequence and annotation, as well as draft sequence and annotation emerging from other Plasmodium sequencing projects. PlasmoDB currently houses information from five parasite species and provides tools for intra- and inter-species comparisons. Sequence information is integrated with other genomic-scale data emerging from the Plasmodium research community, including gene expression analysis from EST, SAGE and microarray projects and proteomics studies. The relational schema used to build PlasmoDB, GUS (Genomics Unified Schema) employs a highly structured format to accommodate the diverse data types generated by sequence and expression projects. A variety of tools allow researchers to formulate complex, biologically-based, queries of the database. A stand-alone version of the database is also available on CD-ROM (P. falciparum GenePlot), facilitating access to the data in situations where internet access is difficult (e.g. by malaria researchers working in the field). The goal of PlasmoDB is to facilitate utilization of the vast quantities of genomic-scale data produced by the global malaria research community. The software used to develop PlasmoDB has been used to create a second Apicomplexan parasite genome database, ToxoDB (http://ToxoDB.org).