Biosynthesis of decorin and glypican
Biosynthesis of decorin and glypican
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DOI：
10.1016/s0945-053x(00)00083-4
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发表时间：
2000-08-01
期刊：
影响因子：
6.9
通讯作者：
Oldberg, Å
中科院分区：
文献类型：
--
作者：
Fansson, LÅ;Belting, M;Oldberg, Å
核心蛋白聚糖和磷脂酰肌醇蛋白聚糖分别是专门的软骨素/硫酸皮肤素和硫酸乙酰肝素取代的蛋白聚糖的两个实例。核心蛋白聚糖是一种分泌产物，而磷脂酰肌醇蛋白聚糖通过糖基-磷脂酰-肌醇（GPI）锚与膜脂质连接。新生的核心蛋白聚糖蛋白进入ER的内腔，而磷脂酰肌醇蛋白聚糖蛋白被转移到预先形成的GPI锚。这两种类型的糖胺聚糖起始于位于特殊共有序列中的Ser残基，并且第一个糖基化步骤构成了共同的途径：连接区域GlcA-Gal-Gal-Xyl-Ser的产生
Decorin and glypican are two examples of exclusively chondroitin/dermatan sulfate and heparan sulfate-substituted proteoglycans, respectively. Decorin is a secretory product, whereas glypican is linked to membrane lipids via a glycosyl-phosphatidyl-inositol (GPI) anchor. The nascent decorin protein enters the lumen of the ER, whereas that of glypican is transferred to the preformed GPI-anchors. Both types of glycosaminoglycuronans are initiated on Ser residues located in special consensus sequences, and the first glycosylation steps constitute a common pathway: the generation of the linkage region GlcA-Gal-Gal-Xyl-Ser