Eccentric target sign in cerebral toxoplasmosis: neuropathological correlate to the imaging feature.
Eccentric target sign in cerebral toxoplasmosis: neuropathological correlate to the imaging feature.
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DOI：
10.1002/jmri.22192
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发表时间：
2010-06
影响因子：
4.4
通讯作者：
Shankar, S. K.
中科院分区：
文献类型：
--
作者：
Kumar, G. G. Sharath;Mahadevan, A.;Guruprasad, A. S.;Kovoor, Jerry M. E.;Satishchandra, P.;Nath, Avindra;Ranga, Udaykumar;Shankar, S. K.
脑弓形虫病仍然是获得性免疫缺陷综合征（艾滋病）患者最常见的局灶性脑损伤之一。颅脑成像的诊断是一项挑战，它与中枢神经系统淋巴瘤、原发性和转移性中枢神经系统肿瘤或其他颅内感染（如结核瘤或脓肿）非常相似。对比后 T1 加权序列的 MR 成像特征被认为是弓形体病的特征，即“偏心目标征”。该影像征象的病理相关性一直是推测性的。在此，我们将尸检证实的艾滋病毒/艾滋病相关脑弓形体病患者的“偏心目标征”的 MR 特征与潜在的组织病理学相关联。 MR 成像上看到的目标的中央增强核心是由一条沿着沟长度延伸的发炎血管产生的，周围是同心的坏死区和由组织细胞和增殖血管组成的壁，其渗透性受损，产生外周增强边缘。
Cerebral toxoplasmosis remains one of the most common focal brain lesions in patients with acquired immune deficiency syndrome (AIDS). Diagnosis is a challenge as on cranial imaging, it closely mimics central nervous system lymphoma, primary and metastatic CNS tumors or other intracranial infections like tuberculoma or abscesses. An MR imaging feature on post contrast T1 weighted sequences considered pathognomonic of toxoplasmosis is the ‘eccentric target sign’. The pathological correlate of this imaging sign has been speculative. Herein we correlate the underlying histopathology to the MR feature of ‘eccentric target sign’ in a patient with autopsy proven HIV/AIDS related cerebral toxoplasmosis. The central enhancing core of the target seen on MR imaging was produced by a leash of inflamed vessels extending down the length of sulcus that was surrounded by concentric zones of necrosis and a wall composed of histiocytes and proliferating blood vessels with impaired permeability producing the peripheral enhancing rim.
影响因子：
1.3
作者：
Brightbill, TC;Post, MJD;Ruiz, A
通讯作者：
Ruiz, A
影响因子：
11.2
作者：
NAVIA, BA;PETITO, CK;PRICE, RW
通讯作者：
PRICE, RW