Whole body insulin resistance in rat offspring of mothers consuming alcohol during pregnancy or lactation: comparing prenatal and postnatal exposure
Whole body insulin resistance in rat offspring of mothers consuming alcohol during pregnancy or lactation: comparing prenatal and postnatal exposure
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DOI：
10.1152/japplphysiol.00751.2003
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发表时间：
2004-01-01
影响因子：
3.3
通讯作者：
Nyomba, BLG
中科院分区：
文献类型：
--
作者：
Chen, L;Nyomba, BLG
本研究探讨了妊娠或哺乳期间母体乙醇 (EtOH) 消耗对成年大鼠后代葡萄糖稳态的影响。在子宫内暴露于 EtOH 后出生体重较小或正常的大鼠以及母亲仅在哺乳期间给予 EtOH 的大鼠中，通过静脉内葡萄糖耐量试验期间的最小模型确定了葡萄糖的处置。所有三个 EtOH 组的葡萄糖耐量指数和胰岛素敏感性指数均下降，但其葡萄糖有效性与对照组没有差异。此外，出生时较小的乙醇大鼠后代的血浆、肝脏和肌肉甘油三酯水平升高。数据显示，无论出生体重如何，怀孕期间接触乙醇都会使身体在以后的生活中出现胰岛素抵抗，但这种效应也会导致生长受限的大鼠出现血脂异常。此外，在哺乳期间接触乙醇后，胰岛素抵抗也很明显。
This study examined the effects of maternal ethanol ( EtOH) consumption during pregnancy or lactation on glucose homeostasis in the adult rat offspring. Glucose disposal was determined by minimal model during an intravenous glucose tolerance test in rats that had a small or normal birth weight after EtOH exposure in utero and in rats whose mothers were given EtOH during lactation only. All three EtOH groups had decreased glucose tolerance index and insulin sensitivity index, but their glucose effectiveness was not different from that of controls. In addition, EtOH rat offspring that were small at birth had elevated plasma, liver, and muscle triglyceride levels. The data show that EtOH exposure during pregnancy programs the body to insulin resistance later in life, regardless of birth weight, but that this effect also results in dyslipidemia in growth-restricted rats. In addition, insulin resistance is also evident after EtOH exposure during lactation.