The association of genetic markers and malaria infection in the Brazilian Western Amazonian region
The association of genetic markers and malaria infection in the Brazilian Western Amazonian region
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DOI：
10.1590/s0074-02762003000400004
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发表时间：
2003-06-01
期刊：
影响因子：
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通讯作者：
Krieger, H
中科院分区：
文献类型：
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作者：
Beiguelman, B;Alves, FP;Krieger, H
几乎所有的个人（182）属于亚马逊河流域人口（葡萄牙，RO，巴西）进行了调查，以确定疟疾的流行病学方面的数据。研究了13种遗传血液多态性（ABO、MNS、Rh、Kell和Duffy系统、触珠蛋白、血红蛋白和葡萄糖-6-磷酸脱氢酶、谷胱甘肽酶、磷酸葡萄糖变位酶、碳酸酐酶、红细胞酸性磷酸酶和酯酶D）。结果表明，Duffy系统与疟疾易感性有关，在其他流行区观察到。此外，也有人提出建议，表明EsD和Rh基因座可能与疟疾的抗性显着相关。如果统计炒作II错误和样本分层可以被排除，假设存在一个因果机制或一个未知的密切相关的基因座参与疟疾感染的易感性可能解释目前的研究结果。
Almost all individuals (182) belonging to an Amazonian riverine population (Portuchuelo, RO, Brazil) were investigated for ascertaining data on epidemiological aspects of malaria. Thirteen genetic blood polymorphisms were investigated (ABO, MNSs, Rh, Kell, and Duffy systems, haptoglobins, hemoglobins, and the enzymes glucose-6-phosphate dehydrogenase, glyoxalase, phosphoglucomutase, carbonic anhydrase, red cell acid phosphatase, and esterase D). The results indicated that the Duffy System is associated with susceptibility to Malaria, as observed in other endemic areas. Moreover, suggestions also arose indicating that the EsD and Rh loci may be significantly associated with resistance to malaria. If statistical hype II errors and sample stratification could be ruled out, hypotheses on the existence of a causal mechanism or an unknown closely linked locus involved in susceptibility to malaria infection may explain the present findings.