Imaging of primary Ewing sarcoma with 13N-L-glutamate.
Imaging of primary Ewing sarcoma with 13N-L-glutamate.
复制标题
使用 13N-L-谷氨酸对原发性尤文肉瘤进行成像。
DOI：
10.1148/radiology.142.2.6119736
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发表时间：
1982
期刊：
影响因子：
19.7
通讯作者：
J. S. Laughlin
中科院分区：
文献类型：
--
作者：
R. Reiman;G. Rosen;A. Gelbard;R. Benua;J. S. Laughlin
11例未经治疗的原发性尤文氏肉瘤患者静脉注射13n标记的l -谷氨酸。7例患者在化疗期间使用该药物和99mtc -二膦酸亚甲基（99mTc-MDP）反复扫描。13n - l -谷氨酸能明显显示未治疗的原发肿瘤；13N标签在肿瘤中的分布有时与99mTc不同。动力学研究表明，肿瘤组织对13N的吸收速度很快。治疗后的重复扫描显示，13n - l -谷氨酸和99mTc-MDP摄取的变化与随后手术后的组织学发现一致。在化疗期间，13N的摄取通常比99mTc的摄取更明显地减少，但13N- l -谷氨酸不能显示转移灶。用这种标记的氨基酸进行肿瘤成像可能对评估原发性尤文氏肉瘤对化疗的反应有价值。
Eleven patients with untreated primary Ewing sarcoma were studied with intravenously administered 13N-labeled L-glutamate. Seven were repeatedly scanned during chemotherapy using this agent and 99mTc-methylene diphosphonate (99mTc-MDP). The untreated primary tumor was distinctly visualized with 13N-L-glutamate in all cases; the distribution of 13N label in the tumor sometimes differed from that of 99mTc. A kinetic study showed rapid uptake of 13N by tumor tissue. Repeat scans following therapy indicated that 13N-L-glutamate and 99mTc-MDP uptake showed changes consistent with histological findings following subsequent surgery. 13N uptake often decreased more markedly than 99mTc uptake during chemotherapy, but metastatic lesions were not visualized with 13N-L-glutamate. Tumor imaging with this labeled amino acid may be of value in assessing the response of primary Ewing sarcoma to chemotherapy.