THE ABERRANT RETINO-RETINAL PROJECTION DURING OPTIC-NERVE REGENERATION IN THE FROG .3. EFFECTS OF CRUSHING BOTH NERVES
THE ABERRANT RETINO-RETINAL PROJECTION DURING OPTIC-NERVE REGENERATION IN THE FROG .3. EFFECTS OF CRUSHING BOTH NERVES
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DOI：
10.1002/cne.901960409
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发表时间：
1981-01-01
影响因子：
2.5
通讯作者：
STELZNER, DJ
中科院分区：
文献类型：
--
作者：
BOHN, RC;STELZNER, DJ
A substantial number of optic axons are misrouted after optic nerve regeneration in the adult frog, R. pipiens. Regenerating axons from a crushed optic nerve are distributed throughout the opposite nerve. The effect of crushing both optic nerves (double crush) on the pattern and degree of axonal misrouting was studied. In 28 frogs both optic nerves were crushed at the same time and animals survived for varying periods before the right eye was injected with 3H-proline and the brain processed for autoradiography 24 h later. In every frog with postoperative survivals longer than 2 wk, labeled axons from the right eye were found in the left optic nerve. When compared to the amount of label seen in frogs in which only the right optic nerve was crushed there was substantially less label within the left nerve of frogs after crushing both nerves. Label was also found only at the edge of the left nerve in material from double crush frogs, unlike that found after single crush. In 4 of 6 frogs where the left nerve was crushed 1 wk after the right nerve, the proximal end of the left nerve was completely filled with label, but more distally, label was found only along the edge of this nerve. Although fewer optic axons were labeled in the opposite optic nerve of double crush frogs, label did extend to the optic disc of that eye. Label was not apparent in the ganglion cell fiber layer of the opposite eye. It was confined to the edge of the optic disc in a space apparently associated with papilledema resulting from crushing the optic nerve of that eye. In 6 frogs the retina of the left eye was removed at the same time the right optic nerve was crushed. Labeled axons of the right eye filled the left optic nerve to the retina-less shell of the left eye. The amount and distribution of axonal misrouting into the opposite optic nerve during optic nerve regeneration is apparently affected by intact or regenerating optic axons from the other eye.
