Preparation of solid lipid nanoparticles using a membrane contactor
Preparation of solid lipid nanoparticles using a membrane contactor
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DOI：
10.1016/j.jconrel.2005.07.023
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发表时间：
2005-11-02
影响因子：
10.8
通讯作者：
Fessi, H
中科院分区：
文献类型：
--
作者：
Charcosset, C;El-Harati, A;Fessi, H
固体脂质纳米粒（SLN）于20世纪90年代初被引入，作为化妆品和药物制剂中固体纳米粒、乳剂和脂质体的替代品。本文研究了一种利用膜接触器制备固体脂质纳米粒的新工艺。在高于脂质熔点的温度下，通过膜孔挤压脂质相，从而形成小液滴。水相在膜组件内循环，并扫走在孔出口处形成的液滴。SLN通过将制备物冷却至室温形成。研究了工艺参数（水相和脂相温度、水相错流速度和脂相压力、膜孔径）对SLN尺寸和脂相通量的影响。结果表明，膜接触器允许脂质相通量在0。15和0.35 in（3）/h m（2），平均SLN尺寸在70和215 nm之间。这种新工艺的优点是其使用方便，通过适当选择工艺参数控制SLN尺寸，以及其放大能力。(c)2005年由Elsevier B. V.出版
Solid lipid nanoparticles (SLN) were introduced at the beginning of the 1990s, as an alternative to solid nanoparticles, emulsions and liposomes in cosmetic and pharmaceutical preparations. The present study investigates a new process for the preparation of SLN using a membrane contactor. The lipid phase is pressed, at a temperature above the melting point of the lipid, through the membrane pores allowing the formation of small droplets. The aqueous phase circulates inside the membrane module, and sweeps away the droplets forming at the pore outlets. SLN are formed by the following cooling of the preparation to room temperature. The influence of process parameters (aqueous phase and lipid phase temperatures, aqueous phase crossflow velocity and lipid phase pressure, membrane pore size) on the SLN size and on the lipid phase flux is investigated. It is shown that the membrane contactor allows the preparation of SLN with a lipid phase flux between 0. 15 and 0.35 in (3)/h m(2), and a mean SLN size between 70 and 215 nm. The advantages of this new process are its facility of use, the control of the SLN size by an appropriate choice of process parameters, and its scaling-up abilities. (c) 2005 Published by Elsevier B.V.