FGF-10 plays an essential role in the growth of the fetal prostate
FGF-10 plays an essential role in the growth of the fetal prostate
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DOI：
10.1016/s0012-1606(03)00250-1
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发表时间：
2003-09-01
影响因子：
2.7
通讯作者：
Cunha, GR
中科院分区：
文献类型：
--
作者：
Donjacour, AA;Thomson, AA;Cunha, GR
前列腺的诱导和分支形态形成依赖于雄激素，雄激素通过间质作用诱导前列腺上皮的发育。间质调节上皮细胞的一种机制是通过分泌生长因子，如FGF-10。我们检查了FGF-10（-/-）小鼠的雄性生殖道，在出生时，大多数雄性第二性器官缺失或萎缩，包括前列腺、精囊、尿道球腺和尾管。在FGF-10（-/-）小鼠的前列腺原、泌尿生殖窦（UGS）中偶见前列腺芽发育。在对照UGS器官培养中，FGF-10（-/-）睾丸产生足够的雄激素来诱导前列腺发育。从FGF-10（-/-）小鼠移植到完整雄性宿主的前列腺雏形生长很少，但显示出一些前列腺分化的迹象。在UGS培养中，通过添加FGF-10和睾酮，部分逆转了FGF-10零表型，导致前列腺芽的形成。在对照组或FGF-10（-/-）型UGS中，单独使用FGF-10不能刺激前列腺芽形成。因此，FGF-10似乎是一种生长因子，是前列腺和其他性器官发育所必需的。(C) 2003 Elsevier Inc.版权所有。
Induction and branching morphogenesis of the prostate are dependent on androgens, which act via the mesenchyme to induce prostatic epithelial development. One mechanism by which the mesenchyme may regulate the epithelium is through secreted growth factors such as FGF-10. We have examined the male reproductive tract of FGF-10(-/-) mice, and at birth, most of the male secondary sex organs were absent or atrophic, including the prostate, seminal vesicle, bulbourethral gland, and caudal ductus deferens. Rudimentary prostatic buds were occasionally observed in the prostatic anlagen, the urogenital sinus (UGS) of FGF-10(-/-) mice. FGF-10(-/-) testes produced sufficient androgens to induce prostatic development in control UGS organ cultures. Prostatic rudiments from FGF-10(-/-) mice transplanted into intact male hosts grew very little, but showed some signs of prostatic differentiation. In cultures of UGS, the FGF-10 null phenotype was partially reversed by the addition of FGF-10 and testosterone, resulting in the formation of prostatic buds. FGF-10 alone did not stimulate prostatic bud formation in control or FGF-10(-/-) UGS. Thus, FGF-10 appears to act as a growth factor which is required for development of the prostate and several other accessory sex organs. (C) 2003 Elsevier Inc. All rights reserved.