Molecular genetic evidence for subtypes of oligoastrocytomas
Molecular genetic evidence for subtypes of oligoastrocytomas
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DOI：
10.1097/00005072-199710000-00003
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发表时间：
1997-10-01
影响因子：
3.2
通讯作者：
vonDeimling, A
中科院分区：
文献类型：
--
作者：
Maintz, D;Fiedler, K;vonDeimling, A
少突星形细胞瘤的组织发生仍然存在争议，一些数据认为少突星形细胞瘤与星形细胞肿瘤相似，其他数据表明与少突胶质细胞肿瘤关系更密切。由于星形细胞瘤的分子遗传学改变与少突胶质细胞瘤不同，我们对120例星形细胞和少突胶质细胞肿瘤（包括38例少突星形细胞瘤）的遗传学改变进行了表征，这些遗传学改变在星形细胞瘤和少突胶质细胞瘤之间不成比例地发生，即TP53基因突变和染色体Ip、17 p和19 q的等位基因丢失。如前所述，TP53突变在星形细胞胶质瘤中很常见，发生在大约一半的WHO II级和III级星形细胞瘤中，但仅发生在5%的WHO II级和III级少突胶质细胞瘤中。然而，染色体Ip和19 q的等位基因丢失在少突胶质细胞瘤中很常见（41%和63%），但在星形细胞瘤中不太常见（9%和35%）。寡星形细胞瘤显示TP 53突变12/38（32%）的情况下，和等位基因丢失的染色体Ip和19 q分别为52%和70%。最重要的是，TP53突变和染色体Ip和19q上的等位基因丢失在寡星形细胞瘤中呈负相关（p <0.011和p <0.019）。这些数据表明，存在两个基因亚型的少突星形细胞瘤，一个基因相关的星形细胞瘤和其他基因相关的少突胶质细胞瘤。组织学上，TP53突变的少突星形细胞瘤更常见星形细胞瘤为主，而染色体19 q缺失的少突胶质细胞瘤更常见。
The histogenesis of oligoastrocytomas remains controversial, with some data arguing similarity of oligoastrocytomas to astrocytic tumors, and other data suggesting closer relationships with oligodendroglial neoplasms. Since the molecular genetic changes in astrocytomas differ from those of oligodendrogliomas, we characterized 120 astrocytic and oligodendroglial tumors, including 38 oligoastrocytomas, for genetic alterations that occur disproportionately between astrocytomas and oligodendrogliomas, i.e. TP53 gene mutations and allelic loss of chromosomes Ip, 17p and 19q. As previously reported, TP53 mutations were common in astrocytic gliomas, occurring in approximately half of WHO grade II and III astrocytomas, but in only 5% of WHO grades II and III oligodendrogliomas. Allelic losses of chromosomes Ip and 19q, however, were common in oligodendrogliomas (41% and 63%), but less frequent in astrocytomas (9% and 35%). Oligoastrocytomas showed TP53 mutations in 12/38 (32%) cases and allelic losses of chromosomes Ip and 19q in 52% and 70%, respectively. Most importantly, TP53 mutations and allelic losses on chromosomes Ip and 19q were inversely correlated in oligoastrocytomas (p < 0.011 and p < 0.019). These data suggest the existence of two genetic subsets of oligoastrocytomas, one genetically related to astrocytomas and the other genetically related to oligodendrogliomas. Histologically, those oligoastrocytomas with TP53 mutations were more often astrocytoma-predominant, while those with chromosome 19q loss were more often oligodendroglioma-predominant.