Arterial Spin Labeling with Simultaneous Multi-Slice Echo Planar Imaging
Arterial Spin Labeling with Simultaneous Multi-Slice Echo Planar Imaging
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DOI：
10.1002/mrm.24994
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发表时间：
2013-12-01
影响因子：
3.3
通讯作者：
Chen, Liyong
中科院分区：
文献类型：
--
作者：
Feinberg, David A.;Beckett, Alexander;Chen, Liyong
目的将同时多层回波平面成像(EPI)与二维(2D)动脉自旋标记(ASL)成像相结合，以获得比目前多层EPI更多的层片，用于测量脑内更大区域的血流灌注。在3特斯拉下对4名受试者进行了测试。使用40个平均值评估从MB-2到MB-5的多频段切片加速因子(MB)。结果在12层数据集中，两次连续采集MB-1图像的空间信噪比分别为3.28和3.44，MB-2和MB-3的空间信噪比分别为3.25和2.98。时间信噪比MB-1平均为1.01和0.99，MB-2为0.89，MB-3为0.78。对于全脑空间覆盖，20个切片数据集可以在更窄的时间窗口内获得，从使用EPI(MB-1)的874ms到使用MB-5的196ms。SMS-EPI ASL不同于3D GASE ASL，后者可以使用背景抑制，并且具有较少的CPMG SE序列的敏感性伪影。结论与基于EPI的ASL成像相比，SMS-EPI具有更大的优势，在不延长采集时间窗口的情况下增加了切片覆盖率。Magn Reson Med 70：1500-1506,2013。(C)2013年威利期刊公司。
PurposeSimultaneous multi-slice (SMS) echo planar imaging (EPI) is incorporated into two-dimensional (2D) arterial spin labeling (ASL) imaging to produce more slices for measuring perfusion in a larger region of the brain than currently possible with multi-slice EPI.MethodsPulsed ASL (PASL) preparations using FAIR and QUIPSS II techniques were combined with SMS-EPI. Testing was performed in four subjects at 3 Tesla. Multiband slice acceleration factors (MB) from MB-2 to MB-5 using 40 averages were evaluated. Comparisons were made quantitatively to PASL 2D EPI and qualitatively to PASL 3D GRASE.ResultsIn the 12 slice data set, spatial SNR for the perfusion weighted images averaged across subjects was 3.28 and 3.44 for the two sequential MB-1 acquisitions as control comparison, 3.25 for MB-2 and 2.98 for MB-3. The temporal SNR averaged 1.01 and 0.99 for MB-1, 0.89 for MB-2, and 0.78 for MB-3. For whole-brain spatial coverage, the 20 slice data sets could be acquired in narrower time windows, from 874 ms using EPI (MB-1) down to 196 ms using MB-5. SMS-EPI ASL differed from 3D GRASE ASL, which can use background suppression and has less susceptibility artifact as a CPMG SE sequence.ConclusionSMS-EPI has a major advantage over EPI-based ASL imaging by increasing slice coverage without lengthening the acquisition time window. Magn Reson Med 70:1500-1506, 2013. (c) 2013 Wiley Periodicals, Inc.