Loss of CDH1 up-regulates epidermal growth factor receptor via phosphorylation of YBX1 in non-small cell lung cancer cells
Loss of CDH1 up-regulates epidermal growth factor receptor via phosphorylation of YBX1 in non-small cell lung cancer cells
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DOI：
10.1016/j.febslet.2013.10.036
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发表时间：
2013-12-11
期刊：
影响因子：
3.5
通讯作者：
Liu, Xiangguo
中科院分区：
文献类型：
--
作者：
Liu, Xianfang;Su, Ling;Liu, Xiangguo
虽然CDH1的缺失通过破坏细胞间的黏附和诱导转录改变来促进肿瘤的转移，但CDH1缺失影响肺癌细胞中EGFR表达的功能途径仍然很大程度上仍不清楚。在本研究中，我们报道了CDH1的下调通过激活YBX1促进了EGFR的转录。此外，CDH1的敲除激活了AKT信号通路，而抑制AKT抑制了CDH1缺失引起的YBX1的磷酸化和EGFR的上调。这些数据表明，CDH1的缺失通过磷酸化的YBX1诱导EGFR的表达，而磷酸化的YBX1通过AKT信号通路激活。(C)2013年欧洲生化学会联合会。爱思唯尔出版，版权所有。
Although loss of CDH1 promotes cancer metastasis by disrupting cell-cell adhesion and inducing transcriptional changes, the functional pathways involved in the loss of CDH1 affecting EGFR expression in lung cancer cells still remain largely unknown. In this study, we report that down-regulation of CDH1 promoted EGFR transcription through activation of YBX1. Furthermore, knockdown of CDH1 activated the AKT signaling pathway, and inhibition of AKT suppressed the phosphorylation of YBX1 and the up-regulation of EGFR induced by CDH1 loss. These data demonstrate that loss of CDH1 induces EGFR expression via phospho-YBX1, which is activated through the AKT signaling pathway. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.