Relationship between non-TRU lung adenocarcinomas and bronchiolar metaplasia - potential implication in their histogenesis -
Relationship between non-TRU lung adenocarcinomas and bronchiolar metaplasia - potential implication in their histogenesis -
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DOI：
10.14670/hh-11-935
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发表时间：
2018-03-01
影响因子：
2
通讯作者：
Ohashi, Kenichi
中科院分区：
文献类型：
--
作者：
Okudela, Koji;Kojima, Yoko;Ohashi, Kenichi
肺腺癌（ADC）大致分为两类：终末呼吸单位（TRU）型和非TRU型。由于它们的细胞形态以及蛋白质表达和遗传改变谱的差异，这些ADC似乎是通过独特的致癌途径发展的。TRU型由非典型腺瘤性增生作为前体发展而来。另一方面，非TRU型的组织发生尚未详细定义。我们在此研究了患有非TRU型ADC的患者的非肿瘤肺组织中的组织病理学变化，以确定其潜在的组织发生。非TRU型优先发生在间质性肺炎患者中，其中肿瘤位于蜂窝状病变中并与细支气管化生（BM）相关。在无间质性肺炎的患者中，来自非TRU型ADC的非肿瘤肺组织经常受到多发性BM的影响。在这些病例中，肿瘤通常与BM相关。与非TRU型ADC相邻的化生细胞异位表达HNF-4 α，这是非TRU型ADC的标志物。这些结果表明，非TRU型通过不同的组织发生发展，其中涉及BM。
Lung adenocarcinomas (ADCs) have been roughly divided into two groups: the terminal respiratory unit (TRU) type and non-TRU type. These ADCs appear to develop through exclusive carcinogenetic pathways because of differences in their cellular morphologies and the profiles of protein expression and genetic alterations. The TRU type develops from atypical adenomatous hyperplasia as a precursor. On the other hand, the histogenesis of the non-TRU type has not yet been defined in detail. We herein investigated histopathological changes in the non-tumor lung tissues of patients with non-TRU-type ADCs in order to define their potential histogenesis. The non-TRU type preferentially occurs in patients with interstitial pneumonia, in whom tumors are located in honeycomb lesions and are associated with bronchiolar metaplasia (BM). Among patients without interstitial pneumonia, non-tumor lung tissues from non-TRU-type ADCs were often affected by multiple BM. In these cases, tumors often were associated with BM. Metaplastic cells adjacent to non-TRU-type ADCs ectopically expressed HNF-4 alpha, a marker for non-TRU-type ADCs. These results suggest that the non-TRU type develops through distinct histogenesis, in which BM is implicated.