The immunoglobulin γ marker 17 allotype and KIR/HLA genes prevent the development of chronic hepatitis B in humans
The immunoglobulin γ marker 17 allotype and KIR/HLA genes prevent the development of chronic hepatitis B in humans
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DOI：
10.1111/imm.13133
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发表时间：
2019-11-12
期刊：
影响因子：
6.4
通讯作者：
Accardi, Giulia
中科院分区：
文献类型：
--
作者：
Di Bona, Danilo;Pandey, Janardan P.;Accardi, Giulia
乙型肝炎病毒（HBV）感染在大多数个体中引起自限性疾病。然而，不到10%的感染者会发展成慢性疾病。宿主在先天免疫和获得性免疫界面的多态性基因的遗传变异，如杀伤免疫球蛋白样受体（KIR）、它们的人类白细胞抗原（HLA）和IgG同种异体（GM），可以解释这种不同的临床图景。我们之前发现了KIR2DL3基因对慢性乙型肝炎（CHB）发展的保护作用，以及KIR配体群HLA-A-Bw4和HLA-C2的有害作用。我们扩大了先前的分析，对GM23和GM3/17同种异型患者进行基因分型。CHB患者与HBV感染者的比较显示，GM17等位基因的存在几乎消除了发生CHB的风险（OR， 0中心点03；95% CI， 0中心点004-0中心点16；P < 0中心点0001）。此外，GM17、KIR2DL3、HLA-A-Bw4和HLA-C2联合检测对预测HBV感染结局具有高度敏感性。
Hepatitis B virus (HBV) infection causes a self-limiting disease in most individuals. However, < 10% of infected subjects develop a chronic disease. Genetic host variability of polymorphic genes at the interface of innate and acquired immunity, such as killer immunoglobulin-like receptors (KIR), their human leucocyte antigen (HLA) and IgG allotypes (GM), could explain this different clinical picture. We previously showed a protective role of the KIR2DL3 gene for the development of chronic hepatitis B (CHB), and a detrimental role of the KIR ligand groups, HLA-A-Bw4 and HLA-C2. We have expanded the previous analysis genotyping patients for GM23 and GM3/17 allotypes. The comparison of the patients with CHB with those who resolved HBV infection showed that the presence of GM17 allele virtually eliminated the risk of developing CHB (OR, 0 center dot 03; 95% CI, 0 center dot 004-0 center dot 16; P < 0 center dot 0001). In addition, the combination of GM17, KIR2DL3, HLA-A-Bw4 and HLA-C2 was highly sensitive to predict the outcome of HBV infection.