Does chronic hyperinsulinemia cause hypertension?
Does chronic hyperinsulinemia cause hypertension?
复制标题
慢性高胰岛素血症会导致高血压吗？
DOI：
10.1093/ajh/2.3.171
复制
发表时间：
1989
影响因子：
3.2
通讯作者：
Mizelle,HL
中科院分区：
文献类型：
--
作者：
Hall,JE;Coleman,TG;Mizelle,HL
本研究的目的是确定慢性高胰岛素血症（与肥胖相关高血压中发现的高胰岛素血症相当）是否会导致平均动脉压（MAP）持续升高或增强血管紧张素II（ANG II）的高血压效应。胰岛素输注（0.5或1.0 mU/kg/min，IV），通过IV葡萄糖输注保持血糖恒定，持续7至28天，使血浆胰岛素增加了5至10倍，但没有显着改变肾脏质量减少的狗的MAP。维持高钠摄入量。在输注ANG II引起轻度高血压的犬中，胰岛素28天未增强高血压。然而，胰岛素输注确实在输注的最初几天内引起适度的钠潴留。这些发现表明，除了高胰岛素血症本身的其他因素是负责肥胖相关的高血压。美国高血压杂志1989;2：171-173
The aim of this study was to determine whether chronic hyperinsulinemia, comparable to that found in obesity-associated hypertension, causes sustained increases in mean arterial pressure (MAP) or potentiates the hypertensive effects of angiotensin II (ANG II). Insulin infusion (0.5 or 1.0 mU/kg/min, IV), with plasma glucose held constant by IV glucose infusion, for seven to 28 days raised plasma insulin by five- to ten-fold, but did not significantly change MAP in dogs with reduced kidney mass that were maintained on high sodium intake. In dogs infused with ANG II to cause mild hypertension, insulin for 28 days did not potentiate the hypertension. Insulin infusion did, however, cause modest sodium retention during the first few days of infusion. These findings suggest that additional factors besides hyperinsulinemia per se are responsible for obesity-associated hypertension. Am J Hypertens 1989;2:171–173