Wheel running, voluntary ethanol consumption, and hedonic substitution
Wheel running, voluntary ethanol consumption, and hedonic substitution
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DOI：
10.1016/j.alcohol.2008.04.006
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发表时间：
2008-08-01
期刊：
影响因子：
2.3
通讯作者：
Blednov, Yuri A.
中科院分区：
文献类型：
--
作者：
Ozburn, Angela Renee;Harris, R. Adron;Blednov, Yuri A.
很少有研究调查小鼠的自然奖励行为和酒精饮用行为之间的关系。虽然自然强化物和药物强化物激活了相似的大脑回路，但有行为证据表明，食物和药物奖励在感知价值上是不同的。本研究的主要目的是探讨C57BL/6J小鼠自然强化刺激与乙醇消耗之间的关系。观察小鼠在以下环境操作下的行为：标准或增强环境，可及或不可及的轮子，存在或不存在乙醇。使用高分辨率体积饮酒监测仪和车轮运行监测仪，我们评估了交替进入车轮运行是否会改变乙醇相关行为，以及交替进入乙醇是否会改变车轮运行或随后的乙醇相关行为。我们发现乙醇消耗量在轮毂交替运行期间保持稳定。车轮运转在没有乙醇时增加，在重新引入乙醇时减少。在重新引入乙醇后，可以看到酒精剥夺效应。总的来说，这些结果支持了享乐替代理论，并表明雌性C57BL/6J小鼠在这些特定条件下表达了乙醇寻求和渴望。(c) 2008爱思唯尔公司版权所有。
Few studies have examined the relationship between naturally rewarding behaviors and ethanol drinking behaviors in mice. Although natural and drug reinforcers activate similar brain circuitry, there is behavioral evidence suggesting food and drug rewards differ in perceived value. The primary goal of the present study was to investigate the relationships between naturally reinforcing stimuli and consumption of ethanol in ethanol preferring C57BL/6J mice. Mouse behaviors were observed after the following environmental manipulations: standard or enhanced environment, accessible or inaccessible wheel, and presence or absence of ethanol. Using a high-resolution volumetric drinking monitor and wheel running monitor, we evaluated whether alternating access to wheel running modified ethanol-related behaviors and whether alternating access to ethanol modified wheel running or subsequent ethanol-related behaviors. We found that ethanol consumption remains stable with alternating periods of wheel running. Wheel running increases in the absence of ethanol and decreases upon reintroduction of ethanol. Upon reintroduction of ethanol, an alcohol deprivation effect was seen. Collectively, the results support theories of hedonic substitution and suggest that female C57BL/6J mice express ethanol seeking and craving under these specific conditions. (c) 2008 Elsevier Inc. All rights reserved.