MATERNAL THYROID HORMONE LEVELS IN PREGNANCY AND THE SUBSEQUENT COGNITIVE AND MOTOR PERFORMANCE OF THE CHILDREN
MATERNAL THYROID HORMONE LEVELS IN PREGNANCY AND THE SUBSEQUENT COGNITIVE AND MOTOR PERFORMANCE OF THE CHILDREN
复制标题
怀孕期间母亲的甲状腺激素水平以及随后孩子的认知和运动表现
作者：
P. Pharoah;K. Connolly;R. Ekins;A. G. Harding
对巴布亚新几内亚高地严重缺碘地区妇女妊娠期间甲状腺素和三碘甲状腺原氨酸的血清水平进行了测定。随后，这些妇女所生的孩子在10 - 12岁时接受了检查，并测量了智力和运动能力。观察到儿童的这些指标与母亲的甲状腺素水平有显著相关性，但与母亲的三碘甲状腺原氨酸水平无关。推测母体甲状腺素而非三碘甲状腺原氨酸可能在胎儿甲状腺功能发育前对胎儿正常的神经系统成熟至关重要。
Serum levels of thyroxine and triiodothyronine during pregnancy were measured in women from a severely iodine deficient region in the highlands of Papua New Guinea. Subsequently the children born to these women were examined when aged 10‐12 years and measures made of intellectual ability and motor competence. A significant correlation between these measures in the children and the maternal thyroxine but not maternal triiodothyronine level was observed. It is speculated that maternal thyroxine and not triiodothyronine may be essential for normal neurological maturation of the fetus before the fetal thyroid becomes functional.