Codon 72 polymorphism (rs1042522) of TP53 is associated with changes in diastolic blood pressure over time
Codon 72 polymorphism (rs1042522) of TP53 is associated with changes in diastolic blood pressure over time
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DOI：
10.1038/ejhg.2011.240
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发表时间：
2012-06-01
影响因子：
5.2
通讯作者：
Dolle, Martijn E. T.
中科院分区：
文献类型：
--
作者：
Reiling, Erwin;Lyssenko, Valeriya;Dolle, Martijn E. T.
P53参与应激反应、新陈代谢和心血管功能。P53基因中rs1042522的C等位基因与长寿和癌症有关。在这项研究中，我们旨在用纵向方法研究rs1042522与血压、BMI和腰围变化的关系。Rs1042522在两项纵向研究中进行了分析：Doetinchem队列研究(DCS)和波特尼亚前瞻性研究(BPS)。根据rs1042522基因型别研究数量性状随时间的变化。观察到rs1042522与dcs中舒张压随时间的变化有关(P=0.004)。此外，随着时间的推移，腰围的变化与腰围的变化之间存在着边缘显著的关联(P=0.03)。在BPS中也观察到了这些改变(P=0.02和P=0.05)。C/C-基因型(Pro/Pro)在所研究的终点显示出最温和的时间相关增加。此外，来自BPS的数据表明，在口服葡萄糖耐量试验中，随着时间的推移，C/C基因型对血糖水平的升高具有保护作用(P=0.01和P=0.02)。总之，我们发现rs1042522的C/C基因型与舒张压和腰围随时间的变化有关。这可能与其他人观察到的相同基因的长寿表型有关。《欧洲人类遗传学杂志》(2012年)20696700；DOI：10.1038/ejhg.2011.240；2011年12月21日在线发布
p53 is involved in stress response, metabolism and cardiovascular functioning. The C-allele of rs1042522 in the gene encoding for p53 is associated with longevity and cancer. In this study, we aimed to investigate the association of rs1042522 with changes in blood pressure, BMI and waist circumference using a longitudinal approach. Rs1042522 was analyzed in two longitudinal studies; the Doetinchem Cohort Study (DCS) and the Botnia Prospective Study (BPS). Changes in quantitative traits over time were investigated according to rs1042522 genotypes. An association between rs1042522 and changes in diastolic blood pressure (DBP) in the DCS over time was observed (P=0.004). Furthermore, a borderline significant association was detected with changes in waist circumference over time (P=0.03). These findings were also observed in the BPS (P=0.02 and P=0.05). The C/C-genotype (Pro/Pro) showed the most moderate time-related increase for the studied endpoints. Furthermore, data from the BPS suggested that the C/C-genotype protects against increases in glucose levels over time at 30 and 60 min during oral glucose tolerance test (P=0.01 and P=0.02). In conclusion, we found an association between the C/C-genotype of rs1042522 and changes in DBP and waist circumference over time. This might contribute to the longevity phenotype observed for the same genotype by others. European Journal of Human Genetics (2012) 20, 696-700; doi:10.1038/ejhg.2011.240; published online 21 December 2011