Simultaneous determination of bisphenol A and its halogenated derivatives in river water by combination of isotope imprinting and liquid chromatography-mass spectrometry
Simultaneous determination of bisphenol A and its halogenated derivatives in river water by combination of isotope imprinting and liquid chromatography-mass spectrometry
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DOI：
10.1016/j.chroma.2006.08.072
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发表时间：
2006-11-17
影响因子：
4.1
通讯作者：
Haginaka, Jun
中科院分区：
文献类型：
--
作者：
Sambe, Haruyo;Hoshina, Kaori;Haginaka, Jun
以4-乙烯基吡啶为功能单体，乙二醇二甲基丙烯酸酯为交联剂，采用多级溶胀聚合法制备了[H-2(16)]双酚A （BPA-d(16)）的受限介质-分子印迹聚合物（RAM-MIP），然后以二甲基丙烯酸甘油和单甲基丙烯酸甘油为亲水单体进行了表面改性。所制备的RAM-MIP对作为模板分子的BPA、BPA-d(6)和BPA-d16具有良好的分子识别能力，对四氯双酚A （Cl-4-BPA）和四溴双酚A （Br-4-BPA）具有良好的分子识别能力。接下来，利用RAM-MIP对河流水样中的BPA、Cl-4-BPA和Br-4-BPA进行选择性在线预处理和富集，并通过LC-MS分离和测定。以BPA-d(6)为内标构建了BPA、Cl-4-BPA和Br-4-BPA的标定图，在12.5 ~ 200 pg/mL （r > 0.999）范围内呈良好的线性关系。25 pg/mL时BPA、Cl-4-BPA和Br-4-BPA的日间精密度分别为1.08、3.67和1.58%。该方法成功地应用于河水中双酚a及其卤化衍生物的同时测定。(c) 2006 Elsevier B.V.版权所有
A restricted access media-molecularly imprinted polymer (RAM-MIP) for [H-2(16)]bisphenol A (BPA-d(16)) was prepared by a multi-step swelling and polymerization method using 4-vinylpyridine as a functional monomer and ethylene glycol dimethacrylate as a cross-linker, followed by hydrophilic surface modification using glycerol dimethacrylate and glycerol monomethacrylate as hydrophilic monomers. The obtained RAM-MIP showed excellent molecular recognition abilities for BPA and BFA-d(6) as well as BPA-d16 used as the template molecule, and good ones for tetrachlorobisphenol A (Cl-4-BPA) and tetrabromobisphenol A (Br-4-BPA). Next, the RAM-MIP was utilized for selective on-line pretreatment and enrichment of BPA, Cl-4-BPA and Br-4-BPA in a river water sample, followed by their separation and determination by LC-MS. The calibration graphs of BPA, Cl-4-BPA and Br-4-BPA, constructed using BPA-d(6) as an internal standard, showed good linearity in the range of 12.5-200 pg/mL (r > 0.999) with a 2-mL injection of a river water sample. The inter-day precision data for the assay of BPA, Cl-4-BPA and Br-4-BPA at 25 pg/mL were 1.08, 3.67 and 1.58%, respectively. Furthermore, this method was successfully applied for the simultaneous determination of BPA and its halogenated derivatives in river water. (c) 2006 Elsevier B.V. All rights reserved.