Effect of oxymetazoline nasal spray on intraocular pressure and retrobulbar hemodynamics
Effect of oxymetazoline nasal spray on intraocular pressure and retrobulbar hemodynamics
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DOI：
10.2310/7070.2005.4102
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发表时间：
2006-02-01
期刊：
影响因子：
--
通讯作者：
Koç, C
中科院分区：
文献类型：
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作者：
Arikan, OK;Akarsu, C;Koç, C
目的：研究羟甲唑啉鼻腔喷雾剂对开角型青光眼患者眼压和球后血流动力学的影响，并与健康对照组的结果进行比较。前瞻性临床试验。地点：大学医院。方法：30名开角型青光眼患者和30名健康志愿者接受自控喷雾剂滴鼻，每天3次(每个鼻孔喷雾剂浓度为0.05%)，连续5天。主要观察指标：青光眼患者和正常眼在用药前和用药结束时测量眼压和球后血流动力学。结果：青光眼组和对照组用药5天后眼压均显著降低(P=.02)和对照组(P=.001)。在研究期间，青光眼组和对照组的系统参数(收缩压，p=.14和p=.17；舒张压，p=.18和p=.49；脉率，p=.06和p=.50)没有显示出统计学上的显著差异。此外，除了青光眼患者视网膜中央动脉的阻力指数显著降低(p=.001)外，青光眼组和对照组的球后血流动力学均未发生明显变化。结论：羟甲唑啉鼻喷雾剂治疗5天后，无论是健康对照组还是青光眼患者，均可降低眼压。此外，它对球后血流动力学没有明显的不良影响。
Objectives: To determine the effect of oxymetazoline nasal spray on intraocular pressure and retrobulbar hemodynamics in patients with open-angle glaucoma and to compare the results with those measured in healthy control participants.Study Design: Controlled, prospective clinical trial.Setting: University hospital.Methods: Thirty patients with open-angle glaucoma and 30 healthy volunteers as controls were topically self-administered oxymetazoline nasal spray three times a day (one spray in each nostril of 0.05% concentration) for 5 days continuously.Main Outcome Measures: Intraocular pressure and retrobulbar hemodynamics were measured in glaucomatous and normal eyes at baseline and at the end of oxymetazoline application.Results: Oxymetazoline nasal spray lowered intraocular pressure significantly in both the glaucoma group (p = .02) and the control group (p = .001) after 5 days of treatment. The systemic parameters in the glaucoma and control groups (systolic blood pressure, p = .14 and p = .17; diastolic blood pressure, p = .18 and p = .49; and pulse rate, p = .06 and p = .50, respectively) did not show statistically significant differences during the study period. Additionally, except with a significant decrease in the resistivity index of the central retinal artery in the glaucoma patients (p = .001), oxymetazoline nasal spray did not result in any significant changes in the retrobulbar hemodynamics in both the glaucoma and control groups.Conclusions: This study showed that a 5-day treatment with oxymetazoline nasal spray reduced intraocular pressure in both healthy controls and patients with glaucoma under treatment. In addition, it had no significant adverse effects on the retrobulbar hemodynamics.