Weight characteristics and height in relation to risk of gestational diabetes mellitus
Weight characteristics and height in relation to risk of gestational diabetes mellitus
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DOI：
10.1093/aje/kwk007
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发表时间：
2007-02-01
影响因子：
5
通讯作者：
Williams, Michelle A.
中科院分区：
文献类型：
--
作者：
Rudra, Carole B.;Sorensen, Tanya K.;Williams, Michelle A.
超重和肥胖患病率的增加促使我们对妊娠期糖尿病与自我报告的成人身高、体重和体重波动进行前瞻性检查。通过使用 1996 年至 2002 年间在西雅图和华盛顿州塔科马登记的 1,644 名女性的病历来评估妊娠期糖尿病。调整后，风险与身高呈负相关，与孕前体重指数呈正相关（p（趋势）< 0.001）。 18 岁时与体重指数的关系呈 J 形，与正常体重女性相比，瘦女性（调整后相对风险 (RR) = 1.79，95% 置信区间 (CI)：1.01, 2.84）和肥胖女性（RR = 4.53，95% CI：1.25, 16.43）的风险较高。 18 岁至研究怀孕之间的体重增加与风险增加相关，与 18 岁时体重指数和其他混杂因素无关（>= 10 公斤增加 vs. < 2.5 公斤变化：RR = 3.43，95% CI：1.60，7.37）。调整 18 岁时体重指数和成人体重变化后，体重循环（体重减轻和恢复 >= 6.8 kg）不相关（>= 3 与零循环：RR = 1.23，95% CI：0.56，2.73）。成年期间体重增加 10 公斤或以上的女性中，骑自行车没有显着相关（>= 3 次与零次循环：RR = 2.04，95% CI：0.83，5.02）。努力预防年轻女性肥胖和体重增加可能会降低妊娠期糖尿病的风险。
Increasing prevalence of overweight and obesity motivated this prospective examination of gestational diabetes mellitus in relation to self-reported adult height, weight, and weight fluctuation. Gestational diabetes was assessed by use of medical records in 1,644 women enrolled in Seattle and Tacoma, Washington, between 1996 and 2002. After adjustment, risk was inversely related to height and directly related to pregravid body mass index (p(trend) < 0.001). The relation with body mass index at age 18 years was J shaped, with higher risk among lean women ( adjusted relative risk (RR) = 1.79, 95% confidence interval (CI): 1.01, 2.84) and obese women ( RR = 4.53, 95% CI: 1.25, 16.43) versus normal-weight women. Weight gain between age 18 years and the study pregnancy was associated with increased risk independently of body mass index at 18 years and other confounders (>= 10-kg gain vs. < 2.5-kg change: RR = 3.43, 95% CI: 1.60, 7.37). Weight cycling ( loss and regain of >= 6.8 kg) was not associated after adjustment for body mass index at 18 years and adult weight change (>= 3 vs. zero cycles: RR = 1.23, 95% CI: 0.56, 2.73). Cycling was nonsignificantly related among women who gained 10 kg or more during adulthood (>= 3 vs. zero cycles: RR = 2.04, 95% CI: 0.83, 5.02). Efforts to prevent obesity and weight gain among young women may reduce gestational diabetes risk.